A cohort study of nutritional factors and endometrial cancer
A cohort study of nutritional factors and endometrial cancer
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DOI：
10.1023/a:1011012621990
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发表时间：
2000-01-01
影响因子：
13.6
通讯作者：
Miller, AB
中科院分区：
文献类型：
--
作者：
Jain, MG;Rohan, TE;Miller, AB
为了评估营养因素在子宫内膜癌病因中的作用，我们使用了1980至1985年间参加加拿大全国乳房筛查研究的妇女的数据进行了病例队列分析。在这项分析中，从饮食队列中的56,837名女性中随机抽取10%的样本，建立了一个子队列。这些病例是在1993年12月31日的随访中被诊断为子宫内膜腺癌的221名妇女，并通过与加拿大癌症数据库的记录链接来确定。通过自填式问卷收集登记时通常饮食和其他流行病学变量的信息。风险比从比例风险回归模型中获得，并估计稳健的标准误差。我们发现子宫内膜癌与体重指数25 kg/m(2)有很强的相关性(危险比2.72，95%CI：2.06-3.50)。子宫内膜癌的风险与总能量、碳水化合物、蛋白质、总脂肪和主要脂肪酸、总膳食纤维和各种纤维、维生素C、E和A、叶酸、β-胡萝卜素、叶黄素或隐黄素的摄入量无关。饱和脂肪、动物脂肪或番茄红素的摄入量相对较高，风险也有所降低。研究中观察到的关联与总能量摄入量和大多数非饮食风险因素无关。这项研究表明，加拿大女性的饮食能量摄入量和大多数主要营养素与子宫内膜癌的风险无关。
To evaluate the role of nutritional factors in the etiology of endometrial cancer, we performed a case-cohort analysis using data from women enrolled in the National Breast Screening Study in Canada from 1980 to 1985. For this analysis, a subcohort was constructed by selecting a 10% random sample from the 56,837 women in the dietary cohort. Cases were the 221 women diagnosed with incident adenocarcinoma of the endometrium during follow-up to December 31, 1993 and ascertained by record linkage to the Canadian Cancer Database. Information on usual diet at enrolment and other epidemiological variables was collected by means of self-administered questionnaires. Hazard ratios were obtained from proportional hazards regression models, with estimation of robust standard errors. We found a strong association of endometrial cancer with body mass index > 25 kg/m(2) (hazard ratio 2.72, 95% CI: 2.06-3.50). Endometrial cancer risk was not associated significantly with intakes of total energy, carbohydrates, proteins, total fat and major fatty acids, total dietary fiber and various types of fibers, vitamin C, E and A, folic acid, beta -carotene, lutein, or cryptoxanthin. Some decrease in risk was noted with relatively high intakes of saturated fat, animal fat or lycopene. The associations observed in the study were independent of total energy intake and most non-dietary risk factors. The study suggests that dietary intakes of energy and most major nutrients are not related to the risk of endometrial cancer among Canadian women.