Obesity is associated with increased risk of first trimester and recurrent miscarriage: matched case-control study
Obesity is associated with increased risk of first trimester and recurrent miscarriage: matched case-control study
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DOI：
10.1093/humrep/deh277
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发表时间：
2004-07-01
影响因子：
6.1
通讯作者：
Sturdee, DW
中科院分区：
文献类型：
--
作者：
Lashen, H;Fear, K;Sturdee, DW
背景：肥胖已成为全球主要的健康问题，也与不良妊娠结局有关。这项研究的目的是评估肥胖对公众流产风险的影响。方法：采用巢式病例对照研究。研究人群从产妇数据库中确定。肥胖[体重指数（BMI）>30 kg/m2]女性与年龄匹配的正常BMI对照组（19-24.9 kg/m2）进行比较。研究中仅纳入了未经产的女性，以避免多次纳入受试者，并能够正确识别复发性流产。早期（妊娠6-12周）、晚期（妊娠12-24周）和复发性早期流产（REM）（连续流产3次以上）的患病率
BACKGROUND: Obesity has become a major health problem worldwide and is also associated with adverse pregnancy outcome. The aim of this study was to assess the impact of obesity on the risk of miscarriage in the general public. METHODS: This was a nested case-control study. The study population was identified from a maternity database. Obese [body mass index (BMI) >30 kg/m(2)] women were compared with an age-matched control group with normal BMI (19-24.9 kg/m(2)). Only primiparous women were included in the study to avoid including the subject more than once, and to be able to correctly identify recurrent miscarriages. The prevalence of a previous history of early (6-12 weeks gestation), late (12-24 weeks gestation) and recurrent early miscarriages (REM) (more than three successive miscarriages