Effects of behavioral therapy or pharmacotherapy on brain glucose metabolism in subjects with obsessive-compulsive disorder as assessed by brain FDG PET
Effects of behavioral therapy or pharmacotherapy on brain glucose metabolism in subjects with obsessive-compulsive disorder as assessed by brain FDG PET
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DOI：
10.1016/j.pscychresns.2010.08.012
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发表时间：
2010-11-30
影响因子：
2.3
通讯作者：
Obrocki, Jost
中科院分区：
文献类型：
--
作者：
Apostolova, Ivayla;Block, Suzette;Obrocki, Jost
这项前瞻性研究探讨了药物疗法(PT)和认知行为疗法(CBT)对成人强迫症(OCD)患者脑糖代谢的影响。对16例确诊至少2年的强迫症患者(PT：n=7)进行了F-18-氟代脱氧葡萄糖(FDG)脑动态正电子发射断层扫描(PET)。分别评估治疗有效组和无反应组治疗前后局部葡萄糖代谢速率(SLMRGlc)的变化。SLMRGlc的变化与强迫症、抑郁或焦虑症状的变化之间的相关性被检验。治疗成功后，右侧尾状核SLMRGlc升高。这一增加倾向于与强迫症症状严重程度的改善相关。治疗成功后，发现局部尾状核活动增加，这与之前的大多数研究形成了鲜明对比。可能的解释包括治疗对伴随的抑郁症状的影响和/或在本样本中早发性强迫症的很大比例。(C)2010爱思唯尔爱尔兰有限公司。保留所有权利。
This prospective study investigated the effect of pharmacotherapy (PT) and cognitive behavioral therapy (CBT) on cerebral glucose metabolism in adults with obsessive-compulsive disorder (OCD). Dynamic positron emission tomography (PET) of the brain with F-18-fluorodeoxyglucose (FDG) was performed before and after treatment in 16 subjects diagnosed for OCD for at least 2 years (PT: n = 7). Pre-to-post-treatment change of scaled local metabolic rate of glucose (SLMRGlc) was assessed separately in therapy responders and non-responders. Correlation was tested between SLMRGlc change and change of OCD, depression, or anxiety symptoms. SLMRGlc increased in the right caudate after successful therapy. The increase tended to correlate with the improvement of OCD symptom severity. The finding of increased local caudate activity after successful therapy is in contrast to most previous studies. Possible explanations include effects of therapy on concomitant depression symptoms and/or the large proportion of early-onset OCD in the present sample. (C) 2010 Elsevier Ireland Ltd. All rights reserved.