Development of a Germanium Small-Animal SPECT System.
Development of a Germanium Small-Animal SPECT System.
复制标题
锗小动物 SPECT 系统的开发。
DOI：
10.1109/tns.2015.2448673
复制
发表时间：
2015
影响因子：
1.8
通讯作者：
Peterson,ToddE
中科院分区：
文献类型：
--
作者：
Johnson,LindsayC;Ovchinnikov,Oleg;Shokouhi,Sepideh;Peterson,ToddE
制造技术、电子学和机械冷却系统的进步催生了适合于生物医学成像的锗探测器。我们正在开发一种使用双面GE条状探测器的小动物SPECT系统。探测器出色的能量分辨率可能有助于减少散射并简化多同位素成像的处理，而其测量相互作用深度的能力有可能减少针孔成像中的视差误差。该探测器在140keV下的能量分辨率为1%半高宽，空间分辨率约为1.5 mm半高宽。所描述的原型系统有一个直径为1 mm的单针孔准直器，开口角为70度，焦距在4.5到9 cm之间变化。来自龙门安装系统的幻影图像被提供，包括NEMA NU-2008幻影和热棒幻影。此外，在没有串扰校正的情况下，用99mTc和123I对双同位素体模进行成像，证明了能量分辨率的好处。
Advances in fabrication techniques, electronics, and mechanical cooling systems have given rise to germanium detectors suitable for biomedical imaging. We are developing a small-animal SPECT system that uses a double-sided Ge strip detector. The detector's excellent energy resolution may help to reduce scatter and simplify processing of multi-isotope imaging, while its ability to measure depth of interaction has the potential to mitigate parallax error in pinhole imaging. The detector's energy resolution is <; 1% FWHM at 140 keV and its spatial resolution is approximately 1.5 mm FWHM. The prototype system described has a single-pinhole collimator with a 1-mm diameter and a 70-degree opening angle with a focal length variable between 4.5 and 9 cm. Phantom images from the gantry-mounted system are presented, including the NEMA NU-2008 phantom and a hot-rod phantom. Additionally, the benefit of energy resolution is demonstrated by imaging a dual-isotope phantom with99mTc and123I without cross-talk correction.