Encapsulation of phenylacetic acid in block copolymer nanoparticles during polymerization induced self‐assembly
Encapsulation of phenylacetic acid in block copolymer nanoparticles during polymerization induced self‐assembly
复制标题
聚合诱导自组装过程中苯乙酸封装在嵌段共聚物纳米颗粒中
DOI：
10.1002/aic.18014
复制
发表时间：
2023
期刊：
影响因子：
3.7
通讯作者：
Ricarte, Ralm G.
中科院分区：
文献类型：
--
作者：
Li, Guanrui;Barzycki, Daniel C.;Ricarte, Ralm G.
聚合诱导自组装（PISA）是制备嵌段共聚物纳米颗粒的一种常用方法。在药物存在的情况下进行PISA会导致纳米颗粒包裹药物。虽然这种方法很简单，但药物负载和嵌段共聚物组成的影响尚不清楚。在这里，我们研究了药物苯乙酸（PA）在聚（单甲基丙烯酸甘油）-阻断-聚（2 -羟丙基甲基丙烯酸酯）（PGMA - PHPMA）纳米颗粒中的包封。通过电子显微镜和光散射表征纳米颗粒的形态，同时通过核磁共振扩散测定法量化包封效率（）。增加PA负载使纳米颗粒的形态从球形胶束转变为圆柱形胶束囊泡。在32 mg/ml PA负载下，最大可达80%。增加PHPMA的聚合度影响最小。核心块长度的不变性表明，PA与纳米颗粒电晕结合，突出了在PISA过程中亲水块对药物包封的重要性。
Polymerization induced self‐assembly (PISA) is anin situmethod for producing block copolymer nanoparticles. Performing PISA in the presence of a pharmaceutical drug causes the nanoparticles to encapsulate the drug. While this approach is straightforward, the effects of drug loading and block copolymer composition remain unclear. Here, we investigate encapsulation of the drug phenylacetic acid (PA) in poly(glycerol monomethacrylate)‐block‐poly(2‐hydroxypropyl methacrylate) (PGMA‐PHPMA) nanoparticles during PISA. Nanoparticle morphology is characterized by electron microscopy and light scattering, while encapsulation efficiency () is quantified using nuclear magnetic resonance diffusometry. Increasing the PA loading shifts the nanoparticle morphology from spherical micellescylindrical micellesvesicles. At a 32 mg/ml PA loading,maximizes at ~80%. Increasing the PHPMA degree of polymerization minimally impacts. The invariance oftoward core block length suggests that PA binds to the nanoparticle corona, highlighting the importance of the hydrophilic block for drug encapsulation during PISA.