Activation of serum/glucocorticoid-induced kinase 1 (SGK1) is important to maintain skeletal muscle homeostasis and prevent atrophy.
Activation of serum/glucocorticoid-induced kinase 1 (SGK1) is important to maintain skeletal muscle homeostasis and prevent atrophy.
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DOI：
10.1002/emmm.201201443
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发表时间：
2013-01
影响因子：
11.1
通讯作者：
Cohn, Ronald D.
中科院分区：
文献类型：
--
作者：
Andres-Mateos, Eva;Brinkmeier, Heinrich;Burks, Tyesha N.;Mejias, Rebeca;Files, Daniel C.;Steinberger, Martin;Soleimani, Arshia;Marx, Ruth;Simmers, Jessica L.;Lin, Benjamin;Hedderick, Erika Finanger;Marr, Tom G.;Lin, Brian M.;Hourde, Christophe;Leinwand, Leslie A.;Kuhl, Dietmar;Foeller, Michael;Vogelsang, Silke;Hernandez-Diaz, Ivan;Vaughan, Dana K.;Alvarez de la Rosa, Diego;Lang, Florian;Cohn, Ronald D.
在各种神经肌肉状况下，维持骨骼肌量对于一般健康和防止疾病进展是必不可少的。目前，还没有任何治疗方法可以防止这些情况下肌肉质量的进行性下降。冬眠的哺乳动物即使在长时间的固定和饥饿的情况下，也能免受肌肉萎缩的影响。在这里，我们描述了一种潜在的肌肉保存机制，并将其转化为非冬眠哺乳动物。虽然Akt在骨骼肌内稳态中起着既定的作用，但我们发现血清和糖皮质激素诱导的激酶1(SGK1)通过下调蛋白分解和自噬以及增加冬眠期间的蛋白质合成来调节肌肉质量的维持。我们证明了SGK1对于非冬眠哺乳动物在正常和萎缩的条件下，如饥饿和制动，维持骨骼肌的动态平衡和功能至关重要。我们的结果确定了一个新的治疗靶点，以对抗与肌肉退化和萎缩相关的骨骼肌块的丢失。
Maintaining skeletal muscle mass is essential for general health and prevention of disease progression in various neuromuscular conditions. Currently, no treatments are available to prevent progressive loss of muscle mass in any of these conditions. Hibernating mammals are protected from muscle atrophy despite prolonged periods of immobilization and starvation. Here, we describe a mechanism underlying muscle preservation and translate it to non-hibernating mammals. Although Akt has an established role in skeletal muscle homeostasis, we find that serum- and glucocorticoid-inducible kinase 1 (SGK1) regulates muscle mass maintenance via downregulation of proteolysis and autophagy as well as increased protein synthesis during hibernation. We demonstrate that SGK1 is critical for the maintenance of skeletal muscle homeostasis and function in non-hibernating mammals in normal and atrophic conditions such as starvation and immobilization. Our results identify a novel therapeutic target to combat loss of skeletal muscle mass associated with muscle degeneration and atrophy.
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影响因子：
82.9
作者：
Cohn, Ronald D.;van Erp, Christel;Dietz, Harry C.
通讯作者：
Dietz, Harry C.
DOI：
10.1073/pnas.0604816103
发表时间：
2006-07-25
影响因子：
11.1
作者：
Arteaga, Maria Francisca;Wang, Lin;Canessa, Cecilia M.
通讯作者：
Canessa, Cecilia M.
影响因子：
29
作者：
Izumiya, Yasuhiro;Hopkins, Teresa;Walsh, Kenneth
通讯作者：
Walsh, Kenneth
影响因子：
5.6
作者：
Lee, Kisoo;So, Hyekyoung;Choi, Inho
通讯作者：
Choi, Inho
影响因子：
5.3
作者：
Brunet, A;Park, J;Greenberg, ME
通讯作者：
Greenberg, ME