Nitrogen balance and plasma amino acid levels in uremic patients fed an essential amino acid diet.
Nitrogen balance and plasma amino acid levels in uremic patients fed an essential amino acid diet.
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喂食必需氨基酸饮食的尿毒症患者的氮平衡和血浆氨基酸水平。
DOI：
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发表时间：
1974
影响因子：
7.1
通讯作者：
Marian E. Swendseid
中科院分区：
文献类型：
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作者：
J. Kopple;Marian E. Swendseid
提供八种必需L-氨基酸的饮食的营养价值在三个慢性尿毒症男性生活在一个代谢单位进行了评估。为了比较，受试者最初喂食提供22 g主要优质蛋白质的饮食，然后接受含有21 g八种游离必需L-氨基酸的饮食。两种饮食的氮平衡相似，两名患者为阴性，一名为中性。由于氮摄入量较少的氨基酸饮食，它被推断，膳食氮利用更有效地与后者的饮食。血浆中必需和非必需氨基酸的水平与氨基酸饮食保持良好。胱氨酸和组氨酸减少，缬氨酸和可能的苏氨酸增加，后者的饮食。血浆胱氨酸最初升高，其下降的代谢意义尚不清楚。血浆组氨酸的减少支持组氨酸是尿毒症患者必需氨基酸的论点。这些观察结果表明，饮食提供21克的8种必需L-氨基酸可能不足以维持肾衰竭患者的良好营养状态。添加组氨酸和可能的非特异性氮源可以提高这种饮食的营养价值。Am.临床营养学杂志27：806- 812，1974.
The nutritional value of a diet providing the eight essential L-amino acids was assessed in three chronically uremic men living in a metabolic unit. Subjects were fed initially, for comparison, a diet providing 22 g of primarily high quality protein and then received a diet containing 21 g of the eight free essential L-amino acids. Nitrogen balance was similar for each subject with both diets and was negative in two patients and neutral in one. Because nitrogen intake was less with the amino acid diet, it is inferred that dietary nitrogen was utilized more efficiently with the latter diet. Levels of both essential and nonessential amino acids in plasma were well maintained with the amino acid diet. Exceptions were cystine and histidine which decreased, and valine and possibly threonine, which increased with the latter diet. Plasma cystinewas initially elevated and the metabolic significance of its fall is obscure. The decrease in plasma histidine supports the contention that histidine is an essential amino acid in uremia. These observations suggest that a diet providing 21 g of the eight essential L-amino acids may not be adequate for the maintenance of good nutritional status in renal failure. Addition of histidine and possibly a source of nonspecific nitrogen may enhance the nutritional value of this diet. Am. J. Clin. Nutr. 27: 806-8 12, 1974.