THE MICROVASCULATURE IS THE CRITICAL TARGET OF THE IMMUNE-RESPONSE IN VASCULARIZED SKIN ALLOGRAFT-REJECTION
THE MICROVASCULATURE IS THE CRITICAL TARGET OF THE IMMUNE-RESPONSE IN VASCULARIZED SKIN ALLOGRAFT-REJECTION
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DOI：
10.1111/1523-1747.ep12543418
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发表时间：
1980-01-01
影响因子：
6.5
通讯作者：
GALLI, SJ
中科院分区：
文献类型：
--
作者：
DVORAK, HF;MIHM, MC;GALLI, SJ
带血管的第一批人皮肤异体移植物主要是由于广泛和进行性微血管损伤导致缺血和梗死。微血管损伤与细胞免疫应答有关。然而，血管损伤至少在一定程度上是免疫非特异性的，因为移植物床（宿主组织）的血管和移植物本身的血管一样受到损伤。我们得出结论，微血管内皮是人类同种异体皮肤空化移植物免疫反应的关键靶点，这种事件序列——原发性血管损伤随后缺血性梗死——可能在各种实验和临床环境中具有重要意义。
Vascularized first set human skin allografts were rejected largely by a process of extensive and progressive microvaseular damage leading to ischemia and infarction. Microvascular injury was associated with a cellular immune response. However, vessel damage was at least in part immunologically nonspecific because vessels of the graft bed (host tissue) were damaged as well as those of the graft itself. We conclude that the microvascular endothelium is the critical target of the immune response in vacularized skin allografts in man, and that this sequence of events—primary vascular damage followed by ischemic infarction—may have significance in a variety of experimental and clinical settings.