A Pilot Study to Evaluate the Oral Microbiome and Dental Health in Primary Open-Angle Glaucoma.
A Pilot Study to Evaluate the Oral Microbiome and Dental Health in Primary Open-Angle Glaucoma.
复制标题
DOI：
10.1097/ijg.0000000000000465
复制
发表时间：
2017-04
影响因子：
2
通讯作者：
Danias J
中科院分区：
文献类型：
--
作者：
Polla D;Astafurov K;Hawy E;Hyman L;Hou W;Danias J
目的：评估原发性开角型青光眼（POAG）、牙齿健康和口腔微生物群之间的可能关系。方法：病例对照研究在纽约州立大学进行。根据视野和视神经标准，招募成人受试者（40 ~ 87岁）作为POAG病例（n= 119）和非青光眼对照（n= 78）。总体而言，74.6%是非洲裔美国人（AA）。收集病史和口腔健康信息，并进行眼科检查。对28例AA病例和17例对照组的漱口水标本进行细菌DNA含量分析。分析仅限于美籍华人为主要种族群体。结果测量包括天然牙齿的数量、自我报告的牙周健康参数、口腔细菌种类的数量和流行程度。采用Logistic回归评价相关因素和潜在的相互作用。结果：病例与对照组年龄相近（平均分别为62.2岁、60.9岁，P< 0.48），高血压、糖尿病发病频率相近，但男性患者比例较高（P< 0.04）。平均（±SD），患者天然牙数少于对照组[18.0（±11.1）vs. 20.7（±9.4）]。在多变量分析中，年龄越大，天然牙越多与POAG呈负相关[例如，55岁时的比值比（95%可信区间）为1.0 (0.95-1.06)，P= 0.98，而85岁时的比值比为0.87 (0.79-0.96)，P= 0.007]。在分析的受试者子集样本中，病例中链球菌的数量高于对照组（P< 0.03）。结论：牙齿数量（口腔健康指标）和口腔细菌数量的变化可能与青光眼病理有关。牙齿健康和青光眼之间关系的进一步调查是有必要的。
Purpose:To evaluate possible associations between primary open-angle glaucoma (POAG), dental health, and the oral microbiome.Methods:Case-control study was conducted at SUNY Downstate. Adult subjects (40 to 87 y) were recruited as POAG cases (n= 119) and controls without glaucoma (n= 78) based on visual field and optic nerve criteria. Overall 74.6% were African Americans (AA). Information on medical history and oral health was collected and ophthalmologic examinations were performed. Mouthwash specimens (28 AA cases and 17 controls) were analyzed for bacterial DNA amounts. Analyses were limited to AAs as the predominant racial group. Outcome measures included number of natural teeth, self-reported periodontal health parameters, and amounts and prevalence of oral bacterial species. Logistic regression was used to evaluate associated factors and potential interactions.Results:Cases and controls had similar age (mean: 62.2 and 60.9 y, respectively, P> 0.48), and frequency of hypertension, diabetes, but cases had a higher proportion of men (P< 0.04). On average (±SD), cases had fewer natural teeth than controls [18.0 (±11.1) vs. 20.7 (±9.4)]. Having more natural teeth was inversely associated with POAG, in multivariable analyses, at older ages [eg, odds ratio (95% confidence interval) at age 55: 1.0 (0.95-1.06), P= 0.98 vs. at age 85: 0.87 (0.79-0.96), P= 0.007]. Amounts of Streptococci were higher in cases than controls (P< 0.03) in samples from the subset of subjects analyzed.Conclusions:The number of teeth (an oral health indicator) and alterations in the amounts of oral bacteria may be associated with glaucoma pathology. Further investigation of the association between dental health and glaucoma is warranted.