The human gastric bactericidal barrier: mechanisms of action, relative antibacterial activity, and dietary influences.
The human gastric bactericidal barrier: mechanisms of action, relative antibacterial activity, and dietary influences.
复制标题
人胃杀菌屏障：作用机制、相对抗菌活性和饮食影响。
DOI：
10.1093/infdis/159.5.979
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
Haley,ML
中科院分区：
文献类型：
--
作者：
Peterson,WL;Mackowiak,PA;Barnett,CC;Marling-Cason,M;Haley,ML
近一个世纪以来，人们已经认识到胃液作为抵御肠道细菌病原体的早期防线的重要性[1-3]。虽然一些因素（如消化酶、化学成分、抗体）最初被认为有助于胃液的抗菌活性[4,5]，但最近的数据表明，胃杀菌屏障主要依赖于酸[6-9]。不幸的是，人们对这一重要的肠道病原体入侵屏障的性质知之甚少。具体而言，目前尚不清楚肠道细菌病原体对酸性胃液的敏感性是否不同，食物是否干扰了正常的胃屏障，或者胃液的抗菌活性是否可以通过饮食调节（如酒精饮料）来增强。因此，我们进行了调查：(7)表征三种肠致病菌对HC1和乙醇的相对敏感性，(2)比较三种细菌在人胃液中的生存能力，(3)确定胃液的抗菌活性是否因食物的存在而减弱。
The importance of gastric juice as an early line of defense against bacterial enteric pathogens has been recognized for almost a century [1-3]. Although several factors (eg, digestive enzymes, chemical constituents, antibodies) were initially believed to contribute to the antibacterial activity of gastric juice [4, 5], more recent data suggest that the gastric bactericidal barrier is primarily acid dependent [6-9]. Unfortunately, little else is known about the nature of this important barrier to invasion by intestinal patho-gens. Specifically, it is not clear if bacterial enteric patho-gens differ in susceptibility to acidic gastric juice, if the presence of food interferes with the normal gastric bar-rier, or if the antibacterial activity of gastric juice can be augmented through dietary manipulations (eg, alcoholic beverages).Thus, our investigation was undertaken to:(7) characterize the relative susceptibilities to HC1 and ethanol of three species of enteropathogenic bacteria,(2) compare the abilities of the three strains of bacteria to survive in human gastric juice,(3) determine if the antibacterial ac-tivity of gastric juice is weakened by the presence of food,