Transient Protection of Organic Azides from Click Reactions with Alkynes by Phosphazide Formation
Transient Protection of Organic Azides from Click Reactions with Alkynes by Phosphazide Formation
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DOI：
10.1021/acs.orglett.8b01692
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发表时间：
2018-07-06
期刊：
影响因子：
5.2
通讯作者：
Hosoya, Takamitsu
中科院分区：
文献类型：
--
作者：
Meguro, Tomohiro;Yoshida, Suguru;Hosoya, Takamitsu
报道了一种保护有机叠氮化物免于与炔发生点击反应的方法。用 Amphos 处理叠氮化物得到磷叠氮化物，其在点击反应条件下稳定，并且通过用元素硫处理很容易转化回叠氮化物。因此，该方法允许通过位点选择性点击反应轻松修饰叠氮化合物。
A method for protecting organic azides from click reactions with alkynes is reported. Treatment of azides with Amphos affords phosphazides, which are stable under click reaction conditions and are easily converted back to azides by treatment with elemental sulfur. Thus, the method allows for facile modification of azide compounds via site-selective click reactions.