Can Surface Adhesion Drive Cell Rearrangement? Part II: A Geometrical Model
Can Surface Adhesion Drive Cell Rearrangement? Part II: A Geometrical Model
复制标题
表面粘附能驱动细胞重排吗？
DOI：
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发表时间：
1993
期刊：
影响因子：
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通讯作者：
Y. Sawada
中科院分区：
文献类型：
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作者：
F. Graner;Y. Sawada
摘要我们提出了一种新的灵活的，几何和动力学模型的细胞重排。它包括细胞和外部介质之间的自由边界，以自然地解释表面张力效应。来自细胞间粘附和膜弹性的力作用在代表多边形细胞的点上，根据扩展的狄利克雷构造。该模型模拟了均匀细胞集合的聚集和圆化以及短距离细胞运动。然后，我们研究了两种细胞类型的混合物的行为：聚集体吞噬，细胞分散，全部和部分细胞分选，和更奇特的模式，如“位置反转”和棋盘。包括自由边界导致长距离细胞运动，表明细胞表面粘附可以驱动被动生物细胞。
Abstract We present a new flexible, geometrical and dynamical model for cell rearrangement. It includes free boundaries between the cells and the external medium, to account naturally for surface tension effects. The forces deriving from intercellular adhesion and membrane elasticity act on points representing polygonal cells, according to an extended Dirichlet construction. The model simulates the aggregation and rounding of an homogeneous cell collection and short-distance cell movements. We then examine the behaviors of a mixture of two cell types: aggregate engulfment, cell dispersal, total and partial cell-sorting, and more exotic patterns, such as "position reversal" and the checkerboard. Including free boundaries causes long-distance cell movements, suggesting that cell surface adhesion can drive passive biological cells.