The role of mTOR signaling in Alzheimer disease.
The role of mTOR signaling in Alzheimer disease.
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DOI：
10.2741/s310
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发表时间：
2012-01-01
期刊：
影响因子：
--
通讯作者：
Oddo S
中科院分区：
文献类型：
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作者：
Oddo S
β - 淀粉样蛋白（Aβ）和tau蛋白的积聚被认为直接导致或促成了阿尔茨海默病的进行性认知缺陷这一特征。然而，将Aβ和tau蛋白积聚与学习和记忆缺陷联系起来的分子途径仍然难以捉摸。越来越多的证据表明，可溶性形式的Aβ和tau蛋白可通过干扰几种信号级联来阻碍学习和记忆。在这篇综述中，我将展示数据表明雷帕霉素靶蛋白（mTOR）可能在Aβ和tau蛋白诱导的神经退行性变中起作用。
The buildup of Abeta and tau is believed to directly cause or contribute to the progressive cognitive deficits characteristic of Alzheimer disease. However, the molecular pathways linking Abeta and tau accumulation to learning and memory deficits remain elusive. There is growing evidence that soluble forms of Abeta and tau can obstruct learning and memory by interfering with several signaling cascades. In this review, I will present data showing that the mammalian target of rapamycin (mTOR) may play a role in Abeta and tau induced neurodegeneration.