Simultaneous mapping of blood volume and endothelial permeability surface area product in gliomas using iterative analysis of first-pass dynamic contrast enhanced MRI data
Simultaneous mapping of blood volume and endothelial permeability surface area product in gliomas using iterative analysis of first-pass dynamic contrast enhanced MRI data
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DOI：
10.1259/bjr/31662734
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发表时间：
2003-01-01
影响因子：
2.6
通讯作者：
Jackson, A
中科院分区：
文献类型：
--
作者：
Li, KL;Zhu, XP;Jackson, A
我们描述了一种新的方法来计算内皮细胞渗透性表面积产品的动态增强MRI。该技术使用迭代估计将组织残留函数自动分解为血管内和血管外分量，随后用于生成肿瘤血容量，该体积等于根据T-1加权图像计算的相对脑血容量，并针对造影剂泄漏污染进行了校正（rCBV（校正）（T1））和内皮渗透性（k（fp））图。在脑胶质瘤患者（n = 5）中，通过检查间隔2天进行的两次单独检查之间的内皮渗透性和rCBV（校正）（T1）的再现性，对该技术进行了评估。该技术产生的内皮渗透性图似乎没有血管内造影剂的任何贡献。rCBV（校正）（T1）图显示与通过独立获得的动态磁敏感加权MRI检查计算的血容量图密切相关，无残余渗透性效应的证据。结果具有高度可重复性，两次检查的平均值和97.5 μ l内皮渗透性和rCBV之间具有很强的类内相关性（校正后）（T1）该技术具有良好的重现性，能够计算内皮渗透性和rCBV（更正）（T1）从快速获得的数据集的值提供了相当大的优势，传统的方法和支持使用这种方法的治疗监测或新型治疗药物的试验。
We describe a novel method for the calculation of endothelial permeability surface area product from dynamic contrast enhanced MRI. The technique uses iterative estimation to automatically decompose tissue residue function into intravascular and extravascular components, which are subsequently used to generate tumour blood volume, which is equal to relative cerebral blood volume calculated from T-1 weighted images and corrected for contamination by contrast agent leakage (rCBV(corrected)(T1)) and endothelial permeability (k(fp)) maps. The technique was assessed in patients with cerebral glioma (n = 5) by examining the reproducibility of endothelial permeability and rCBV(corrected)(T1) between two separate examinations conducted with a 2-day interval. The technique produces maps of endothelial permeability that appear to be free of any contribution from intravascular contrast agent. Maps of rCBV(corrected)(T1) show close correlation with maps of blood volume calculated from independently acquired dynamic susceptibility weighted MRI examinations, with no evidence of residual permeability effects. The results were highly reproducible with strong intra-class correlation between the two examinations for mean values and for 97.5 percentiles of endothelial permeability and rCBV(corrected)(T1) The excellent reproducibility of this technique and the ability to calculate endothelial permeability and rCBV(corrected)(T1) values from rapidly acquired data sets offer considerable advantages over conventional approaches and support the use of this methodology for therapeutic monitoring or trials of novel therapeutic agents.