Oxidative degradation of 6-selenoguanosine in aqueous solutions.
Oxidative degradation of 6-selenoguanosine in aqueous solutions.
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水溶液中 6-硒代鸟苷的氧化降解。
DOI：
10.1002/jps.2600700615
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发表时间：
1981
影响因子：
3.8
通讯作者：
Beltagy,YA
中科院分区：
文献类型：
--
作者：
Repta,AJ;Beltagy,YA
研究了 6-硒代鸟苷 (NSC 137679)(I) 在水和各种缓冲系统中的降解。通过高压液相色谱法监测水介质中的药物降解。还通过分光光度法研究了 25° 下各种缓冲系统中 I 降解的一些动力学方面。 I 降解为相应的 diselem=nide，在氧存在下产生硒化物和金属硒。这种降解途径与报道的相关硫代化合物的氧化途径不同。
The degradation of 6-selenoguanosine (NSC 137679)(I) in water and in various buffer systems ws investigated. Drug degradation in aqueous media was monitored by high-pressure liquid chromatography. Some kinetic aspects of the degradation of I in various brffer systems at 25° also were studied spectrophotometrically. The degradation, of I to be corresponding diselem=nide, which prouces a selenide and metallic selenium in the presence of oxygen. This degradation pathway differs from that reported for the oxidation of related thio compounds.