Double-blind randomized controlled trial to determine extent of amnesia with midazolam given immediately before general anaesthesia
Double-blind randomized controlled trial to determine extent of amnesia with midazolam given immediately before general anaesthesia
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DOI：
10.1093/bja/aei040
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发表时间：
2005-03-01
影响因子：
9.8
通讯作者：
Russnak, M
中科院分区：
文献类型：
--
作者：
Bulach, R;Myles, PS;Russnak, M
背景。顺行性而非逆行性健忘症在咪达唑仑治疗后得到证实。然而，目前还没有研究表明咪达唑仑是否能引起立即逆行性健忘症。经伦理委员会批准并同意后，40例接受手术和全身麻醉的成年患者随机分为咪达唑仑2 mg、咪达唑仑5 mg、咪达唑仑10 mg或对照组（生理盐水）。从麻醉诱导前12分钟开始测量，在麻醉诱导前8分钟给药。采用海报视觉识别、特定事件回忆、双谱指数（BIS）和镇静视觉模拟评分来衡量咪达唑仑的效果。直到研究药物给药前，两组之间的识别率和回忆率相似，没有证据表明存在逆行性遗忘（所有P < 0.05）。在视觉回忆（P=0.002）和事件回忆（P=0.002）方面存在剂量依赖性恶化
Background. Anterograde, but not retrograde, amnesia has been demonstrated following midazolam administration. However, there have been no studies investigating whether or not immediate retrograde amnesia can be produced with midazolam.Methods. After ethics committee approval and consent, 40 adult patients undergoing surgery and general anaesthesia were randomly allocated to one of four groups: midazolam 2 mg, midazolam 5 mg, midazolam 10 mg or control (normal saline). Measurements were made from 12 min prior to induction of anaesthesia, and the study drug was administered 8 min prior to induction of anaesthesia. Midazolam effects were measured using visual recognition of posters, recall of specific events, bispectral index (BIS) and sedation visual analogue score.Results. Recognition and recall rates were similar between groups up until the time of study drug administration, with no evidence of retrograde amnesia (all P>.3). There was a dose-dependent deterioration in visual recall (P=0.002), event recollection (P