Possible Role of Osteoprotegerin and Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand as Markers of Plaque Instability in Coronary Artery Disease
Possible Role of Osteoprotegerin and Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand as Markers of Plaque Instability in Coronary Artery Disease
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DOI：
10.1177/0003319710370961
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发表时间：
2010-11-01
期刊：
影响因子：
2.8
通讯作者：
Nabih, Mona
中科院分区：
文献类型：
--
作者：
Shaker, Olfat G.;El-Shehaby, Amal;Nabih, Mona
心血管系统产生的骨保护素 (OPG) 增加了 OPG 血清水平的变化可能与冠状动脉疾病 (CAD) 相关的可能性。我们的目的是评估血清 OPG 和可溶性肿瘤坏死因子相关凋亡诱导配体 (s-TRAIL) 在 CAD 病理学中的可能作用及其作为斑块稳定性标志物的用途。共有 80 名男性参与者被分为 3 组：28 名急性心肌梗死 (AMI) 患者、32 名稳定的 CAD 患者和 20 名健康对照者参加了这项研究。与稳定 CAD 和对照参与者相比，急性心肌梗死和 CAD 组表现出显着较高的 OPG 水平和较低的 s-TRAIL 水平。随着 AMI 和稳定 CAD 组中受影响的冠状血管数量的增加，这些结果会更加严重。结论：CAD 患者血清 OPG 升高与 s-TRAIL 降低之间存在关联。循环中 OPG 水平的升高可能是限制进一步血管损伤的重要代偿机制。
Osteoprotegerin (OPG) produced by cardiovascular system raising the possibility that alterations of OPG serum levels may be associated with coronary artery disease (CAD). Our aim is to assess the possible role of serum OPG and soluble tumor necrosis factor-related apoptosis-inducing ligand (s-TRAIL) in the pathology of CAD and their uses as markers of plaque stability. A total of 80 male participants were categorized into 3 groups: 28 patients with acute myocardial infarction (AMI), 32 established stable CAD, and 20 healthy controls were enrolled in this study. Acute myocardial infarction and CAD groups exhibited significantly higher OPG levels and lower s-TRAIL levels compared to the stable CAD and control participants. These results are aggravated as the number of affected coronary vessels increase in AMI and stable CAD groups. Conclusion: There is an association between raised serum OPG and reduced s-TRAIL in patients with CAD. Elevation of circulating OPG levels may represent a crucial compensatory mechanism to limit further vascular damage.