Relationship between atrophy of the medial temporal areas and memory function in elderly adults
Relationship between atrophy of the medial temporal areas and memory function in elderly adults
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老年人内侧颞区萎缩与记忆功能的关系
DOI：
10.1159/000334845
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发表时间：
2012
影响因子：
2.4
通讯作者：
et al
中科院分区：
文献类型：
--
作者：
Shimada H;Kato T;Ito K;Makizako H;Doi T;Yoshida D;et al
目的：本研究旨在确定哪些类型的认知功能与萎缩的双边内侧颞区，包括内嗅皮层（MTA-ERC）在老年adult.Methods：受试者是96名老年人（平均年龄75.3岁）轻度认知功能障碍。受试者接受韦氏记忆量表修订版，逻辑记忆I和II（WMS-R、LM I和II），3和30 min后的Rey复杂图形保持测试（RCF-3 min和RCF-30 min），数字跨度反向（DSB），数字符号编码（DSC），Stroop颜色和单词测试-干扰列表（SCWT-IL）以及磁共振成像（MRI）结果：所有受试者的MTA ERC萎缩与年龄（r = 0.43）、文化程度（r =-0.2 5）、WMS-R、LM I（r =-0.2 1）、DSC（r =-0.32）和SCWT-IL（r = 0.32）均呈显著相关。轻度至中度萎缩组MTA-ERC萎缩与年龄（r = 0.34）、DSC（r =-0.28）和SCWT-IL（r = 0.25）显著相关。重度萎缩组MTA-ERC萎缩与RCF-3min（r =-0.70）和RCF-30min（r =-0.74）显著相关。线性回归模型包括人口统计学变量和认知测试;在所有受试者中，生存逐步分析的两个变量是年龄（β = 0.374）和SCWT-IL（β = 0.247）。年龄（β = 0.301）、RCF-30 min（β =-0.521）和年龄（β = 0.460）分别是轻度至中度萎缩和重度萎缩组的显著变量。结论：执行功能测试如SCWT-IL可作为识别轻度至中度MTA-ERC萎缩的筛查工具，RCF测试的下降可能提示老年MCI患者的重度MTA-ERC萎缩。
Aim:The current study sought to determine which types of cognitive function are related to atrophy of the bilateral medial temporal areas including the entorhinal cortex (MTA-ERC) in elderly adults.Methods:The subjects were 96 elderly adults (mean age 75.3 years) with mild cognitive impairment. Subjects underwent Wechsler Memory Scale-Revised, logical memory I and II (WMS-R, LM I and II), Rey complex figure retention tests after 3 and 30 min (RCF-3 min and RCF-30 min), digit span backword (DSB), digit symbol-coding (DSC), Stroop Color and Word Test-Interference List (SCWT-IL) as well as magnetic resonance imaging (MRI) and were divided into elderly adults without or with mild to moderate MTA-ERC atrophy, and those with severe atrophy.Results:In all subjects, MTA-ERC atrophy showed significant relationships with age (r = 0.43), education (r = –0.25), WMS-R, LM I (r = –0.21), DSC (r = –0.32), and SCWT-IL (r = 0.32). The mild to moderate atrophy group showed significant relationships between MTA-ERC atrophy and age (r = 0.34), DSC (r = –0.28), and SCWT-IL (r = 0.25). In contrast, in the severe atrophy group, MTA-ERC atrophy was correlated significantly with RCF-3 min (r = –0.70) and RCF-30 min (r = –0.74). The linear regression model included demographic variables and cognitive tests; two variables to survive the step-wise analysis were age (β = 0.374) and SCWT-IL (β = 0.247) in all subjects. Age (β = 0.301), and RCF-30 min (β = –0.521) and age (β = 0.460) remained as a significant variable in the mild to moderate atrophy and severe atrophy groups, respectively.Conclusion:Executive function tests such as SCWT-IL may be useful as a screening tool to identify mild to moderate MTA-ERC atrophy and a decline in the RCF test may suggest severe MTA-ERC atrophy in elderly adults with MCI.