Template-Free Synthesis of Hollow/Porous Organosilica-Fe3O4 Hybrid Nanocapsules toward Magnetic Resonance Imaging-Guided High-Intensity Focused Ultrasound Therapy
Template-Free Synthesis of Hollow/Porous Organosilica-Fe3O4 Hybrid Nanocapsules toward Magnetic Resonance Imaging-Guided High-Intensity Focused Ultrasound Therapy
复制标题
无模板合成空心/多孔有机硅-Fe3O4 杂化纳米胶囊用于磁共振成像引导高强度聚焦超声治疗
DOI：
10.1021/acsami.6b10370
复制
发表时间：
2016-11-09
影响因子：
9.5
通讯作者：
Shi, Jianlin
中科院分区：
文献类型：
--
作者：
Ma, Ming;Yan, Fei;Shi, Jianlin
与传统的模板法制备多功能中空介孔二氧化硅纳米粒子（HMSN）不同，本论文采用一种简便的无模板合成方法，制备了一种同时包裹乙酸异戊酯（PeA）和超顺磁性氧化铁的中空/介孔有机硅纳米胶囊（OSNC）（简称PeA@OSNC）。这种新型材料具有超小且均匀的粒径（类似于82 nm）、高表面积（类似于534 m2·g-1）和在水溶液中优异的胶体稳定性。具有相对低沸点（142 ℃）和高挥发性的油相PeA不仅从结构设计的角度在形成大的中空腔体中起关键作用，而且使PeA@OSNC能够在高强度聚焦超声（HIFU）治疗中充当有效的增强剂。此外，Fe 3 O 4纳米粒子（NP）在有机硅壳上的独特卫星状分布提供了PeA@OSNC在体外和体内的优异磁共振成像（MRI）对比能力。更重要的是，这种新型的治疗诊断剂具有良好的生物安全性，这是非常有前途的临床应用在MRI引导的HIFU治疗。
Entirely differing from the common templating-based multistep strategy for fabricating multifunctional hollow mesoporous silica nanoparticles (HMSN), a facile and template-free synthetic strategy has been established to construct a unique hollow/mesoporous organosilica nano-capsule (OSNC) concurrently encapsulating both isopentyl acetate (PeA) liquid and superparamagnetic iron oxides inside (denoted as PeA@OSNC). This novel material exhibits ultrasmall and uniform particle size (similar to 82 nm), high surface area (similar to 534 m(2).g(-1)), and excellent colloidal stability in aqueous solution. The oil-phase PeA with relatively low boiling point (142 degrees C) and high volatility not only plays a crucial role in formation of a large hollow cavity from the viewpoint of structural design but also enables the PeA@OSNC to act as an efficient enhancement agent in high-intensity focused ultrasound (HIFU) therapy. Moreover, the unique satellite-like distribution of Fe3O4 nanoparticles (NP) on the organosilica shell offered excellent magnetic resonance imaging (MRI) contrast capability of PeA@OSNC in vitro and in vivo. More importantly, such a novel theranostic agent has favorable biosafety, which is very promising for future clinical application in MRI-guided HIFU therapy.