Placental mitochondrial dysfunction with metabolic diseases: Therapeutic approaches.
Placental mitochondrial dysfunction with metabolic diseases: Therapeutic approaches.
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DOI：
10.1016/j.bbadis.2020.165967
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发表时间：
2021-01-01
期刊：
影响因子：
--
通讯作者：
Myatt L
中科院分区：
文献类型：
--
作者：
Hebert JF;Myatt L
肥胖和妊娠期糖尿病（GDM）都会导致不良的孕产妇和胎儿结局，包括妊娠并发症、胎儿生长问题、死产和后代成人发病疾病的发育规划。胎盘氧化/硝化应激增加和胎盘（滋养细胞）线粒体呼吸减少与肥胖和GDM母体代谢环境的改变有关。当胎儿是男性时，这种影响尤为明显，这表明胎盘受到性别二态的影响。此外，肥胖和GDM与滋养细胞缺乏灵活性有关，限制了葡萄糖、脂肪酸和谷氨酰胺作为氧化磷酸化底物的转换能力，同样以两性二态的方式进行。在这里，我们回顾了胎盘线粒体功能障碍的机制：它与母胎结局的关系以及胎儿性别的影响。预防胎盘氧化应激和线粒体功能障碍可能改善妊娠结局。我们概述了改善线粒体呼吸缺陷的途径，特别是线粒体靶向抗氧化剂的益处和缺陷。
Both obesity and gestational diabetes mellitus (GDM) lead to poor maternal and fetal outcomes, including pregnancy complications, fetal growth issues, stillbirth, and developmental programming of adult-onset disease in the offspring. Increased placental oxidative/nitrative stress and reduced placental (trophoblast) mitochondrial respiration occur in association with the altered maternal metabolic milieu of obesity and GDM. The effect is particularly evident when the fetus is male, suggesting a sexually dimorphic influence on the placenta. In addition, obesity and GDM are associated with inflexibility in trophoblast, limiting the ability to switch between usage of glucose, fatty acids, and glutamine as substrates for oxidative phosphorylation, again in a sexually dimorphic manner. Here we review mechanisms underlying placental mitochondrial dysfunction: its relationship to maternal and fetal outcomes and the influence of fetal sex. Prevention of placental oxidative stress and mitochondrial dysfunction may improve pregnancy outcomes. We outline pathways to ameliorate deficient mitochondrial respiration, particularly the benefits and pitfalls of mitochondria-targeted antioxidants.
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影响因子：
5.1
作者：
Berdanier, CD;Everts, HB;Mathews, CE
通讯作者：
Mathews, CE
影响因子：
39.2
作者：
BRAY, GA
通讯作者：
BRAY, GA
影响因子：
3.3
作者：
Aldini, Giancarlo;Altomare, Alessandra;Sergio, Francesco
通讯作者：
Sergio, Francesco
DOI：
10.1530/rep-10-0088
发表时间：
2010-09
期刊：
Reproduction (Cambridge, England)
影响因子：
--
作者：
Catalano PM
通讯作者：
Catalano PM
影响因子：
3.8
作者：
Carter, AM
通讯作者：
Carter, AM