Antinociceptive action of hemopressin in experimental hyperalgesia
Antinociceptive action of hemopressin in experimental hyperalgesia
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DOI：
10.1016/j.peptides.2004.10.026
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发表时间：
2005-03-01
期刊：
影响因子：
3
通讯作者：
Ferro, ES
中科院分区：
文献类型：
--
作者：
Dale, CS;Pagano, RDL;Ferro, ES
内源性血红蛋白，源自血红蛋白β链的降解，降低动脉血压，并在伤害感受的实验模型中发挥抗伤害感受作用。从血红蛋白a链中提取的加压素也能降低血压，但其对疼痛的影响尚未得到研究。在这项工作中，我们研究了加压素对炎症性疼痛的影响。同时注射加压素或在使用消炎药2.5 h后注射加压素可恢复由角叉菜胶或缓激肽引起的痛觉过敏。全身给药加压素也能恢复卡拉胶引起的痛觉过敏。纳洛酮不能阻止该肽的抗伤感受作用。这些数据表明，加压素通过独立于阿片受体激活的机制抑制外周痛觉过敏反应。(C) 2004爱思唯尔公司版权所有。
Endogenous hemorphins, derived from degradation of the beta-chain of hemoglobin, lower arterial blood pressure and exert an antinociceptive action in experimental models of nociception. Hemopressin, derived from the a-chain of hemoglobin, also decreases blood pressure, but its effects on pain have not been studied. In this work, we examined the influence of hemopressin on inflammatory pain. Hemopressin reverted the hyperalgesia induced by either carrageenin or bradykinin when injected concomitantly or 2.5 h after the phlogistic agents. Hemopressin administered systemically also reverted the hyperalgesia induced by carrageenin. Naloxone did not prevent the antinociceptive action of this peptide. These data suggest that hemopressin inhibits peripheral hyperalgesic responses by mechanisms independent of opioid receptor activation. (C) 2004 Elsevier Inc. All rights reserved.