EVIDENCE THAT THE DEATH OF MACROPHAGE FOAM CELLS CONTRIBUTES TO THE LIPID CORE OF ATHEROMA
EVIDENCE THAT THE DEATH OF MACROPHAGE FOAM CELLS CONTRIBUTES TO THE LIPID CORE OF ATHEROMA
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DOI：
10.1016/0021-9150(94)05463-s
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发表时间：
1995-04-07
期刊：
影响因子：
5.3
通讯作者：
MITCHINSON, MJ
中科院分区：
文献类型：
--
作者：
BALL, RY;STOWERS, EC;MITCHINSON, MJ
不同阶段的人类动脉粥样硬化病变的切片显示，在早期病变中，脱细胞脂质核心通常紧邻巨噬细胞泡沫细胞集合的最深边缘。具有大脂质核心的晚期病变在靠近核心的侧边缘或肩部处具有可变数量的巨噬细胞泡沫细胞。在早期和晚期病变中，一些最接近核心的巨噬细胞似乎正在死亡。脂质核含有两种物质，在早期病变中仅在巨噬细胞中发现，即蜡样物质和CD 68抗原，但不含可识别的平滑肌细胞肌动蛋白。可以得出结论，巨噬细胞泡沫细胞的死亡有助于脂质核的起源和缓慢扩大。巨噬细胞死亡的原因尚不确定，但正在调查中。
Sections of human atherosclerotic lesions of different stages show that, in early lesions, the acellular lipid core is usually immediately adjacent to the deepest edge of a collection of macrophage foam cells. Advanced lesions with a large lipid core have variable numbers of macrophage foam cells, close to the lateral edges, or shoulders: of the core. In both early and advanced lesions, some of the macrophages nearest the core appear to be dying. Lipid cores contain two materials which in earlier lesions are found only in macrophages, namely ceroid and CD68 antigen, but do not contain recognisable smooth muscle cell actin, It is concluded that death of macrophage foam cells contributes to the origin and slow enlargement of the lipid core. The cause of macrophage death is not yet certain, but is under investigation.