Iodine deficiency, other trace elements, and goitrogenic factors in the etiopathogeny of iodine deficiency disorders (IDD)
Iodine deficiency, other trace elements, and goitrogenic factors in the etiopathogeny of iodine deficiency disorders (IDD)
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碘缺乏症 (IDD) 病因中的碘缺乏、其他微量元素和致甲状腺肿因素
DOI：
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发表时间：
2007
影响因子：
3.9
通讯作者：
F. Delange
中科院分区：
文献类型：
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作者：
C. Thilly;J. Vanderpas;N. Bebe;K. Ntambue;B. Contempré;B. Swennen;R. Moreno‐Reyes;P. Bourdoux;F. Delange
严重的甲状腺肿大、克汀病和其他缺碘疾病(IDD)的主要原因是土壤中的碘缺乏，与食物交换的严重限制有关。除了缺碘的严重程度外，克汀病和其他IDD的频率和症状还受到其他致甲状腺因素和微量元素的影响。因食用解毒效果差的木薯而导致的硫氰酸盐超载就是这样的缺陷。最近，在人类人群中，严重的硒缺乏也与IDD有关，而在动物中，它已被证明通过甲状腺或甲状腺外机制对甲状腺功能起作用。前者涉及由自由基介导的氧化损伤，而后者则意味着对负责将T4转化为T3的脱碘酶的抑制。其中一个结论是：1.甲亢有多种因素；2.IDD是一个重要的公共卫生问题；3.IDD是研究其他微量元素影响的好模型，这些元素在许多人类代谢中的作用被低估了。
Severe goiter, cretinism, and the other iodine deficiency disorders (IDD) have their main cause in the lack of availability of iodine from the soil linked to a severe limitation of food exchanges. Apart from the degrees of severity of the iodine deficiency, the frequencies and symptomatologies of cretinism and the other IDD are influenced by other goitrogenic factors and trace elements. Thiocyanate overload originating from consumption of poorly detoxified cassava is such deficiency. Very recently, a severe selenium deficiency has also been associated with IDD in the human population, whereas in animals, it has been proven to play a role in thyroid function either through a thyroidal or extrathyroidal mechanism. The former involves oxidative damages mediated by free radicals, whereas the latter implies an inhibition of the deiodinase responsible for the utilization of T4 into T3. One concludes that:1.Goiter has a multifactorial origin2.IDD are an important public health problem; and3.IDD are a good model to study the effects of other trace elements whose actions in many human metabolisms have been somewhat underestimated.