The influence of peri-operative blood transfusion during radical hysterectomy on the prognosis of uterine cervical cancer
The influence of peri-operative blood transfusion during radical hysterectomy on the prognosis of uterine cervical cancer
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DOI：
10.1016/s0955-3886(97)90012-6
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发表时间：
1997-03-01
期刊：
影响因子：
--
通讯作者：
Ozaki, M
中科院分区：
文献类型：
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作者：
Azuma, C;Koyama, M;Ozaki, M
为了评估围手术期输血在宫颈癌手术治疗中的临床意义，我们对1982年至1989年间在成人疾病中心获得的145例FIGO期鳞状细胞型宫颈癌患者的临床资料进行了详细的累积生存率分析。累积生存率采用Kaplan Meier法进行统计学分析。145例Ib期癌症患者中，103例被认为进行了完全切除，术后未接受进一步治疗，42例被认为由于累及淋巴结或淋巴血管间隙而进行了不完全切除。前一组接受围手术期输血的79例患者中，69例少于7单位（1400毫升），10例多于8单位（1600毫升）。24例无输血患者累积5年生存率为100%，小于1400ml患者累积5年生存率为91.7%，大于1600ml患者累积5年生存率为90.0%。同样，42例不完全切除组患者围手术期无输血9例，小于1400mt 27例，大于1600mt 6例，5年生存率分别为88.9、77.8和50.0%。无论术后放射治疗情况如何，我们的Ib期宫颈癌患者围手术期不输血的生存率明显高于输血的患者，说明围手术期输血对宫颈癌预后有不利影响。1997爱思唯尔科学有限公司
To evaluate the clinical implications of peri-operative transfusion in the surgical treatment of uterine cervical cancer, a detailed analysis of the cumulative survival rate was performed using clinical data from 145 patients with FIGO stage Ib cervical cancer of the squamous cell type acquired between 1982 and 1989 at the Center for Adult Diseases. The cumulative survival rate was statistically analyzed using the Kaplan Meier method. Of the 145 patients with stage Ib cancer, 103 were considered to have undergone complete excision and received no further treatment post-operatively, and 42 were considered to have undergone incomplete excision because of the involvement of lymph nodes or the lymphovascular space. Of the 79 patients in the former group who received peri-operative transfusion, 69 received less than seven units (1400 mL) and 10 received more than eight units (1600 mL). The cumulative 5-year survival rate was 100% in the 24 patients who received no transfusions, 91.7% in those who received less than 1400 mL, and 90.0% in those who received more than 1600 mL. Similarly, of the 42 patients in the incomplete excision group, nine did not receive any peri-operative transfusion, 27 received less than 1400 mt, and six received more than 1600 mt. The 5-year survival rate in these groups was 88.9, 77.8 and 50.0%, respectively. The survival rate of our patients with stage Ib cervical cancer without peri-operative transfusion was significantly higher than that of those with transfusion, regardless of post-operative irradiation therapy status, indicating that perioperative transfusion has an adverse influence on the prognosis in cervical cancer. (C) 1997 Elsevier Science Ltd.