Keratinocytes express dipeptidyl-peptidase IV (CD26) in benign and malignant skin diseases
Keratinocytes express dipeptidyl-peptidase IV (CD26) in benign and malignant skin diseases
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DOI：
10.1111/j.1365-2133.1996.tb07941.x
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发表时间：
1996-06-01
影响因子：
10.3
通讯作者：
Bernengo, MG
中科院分区：
文献类型：
--
作者：
Novelli, M;Savoia, P;Bernengo, MG
应用免疫组化技术研究了正常和病理皮肤角质形成细胞上CD26的表达。在正常皮肤中发现了散发性局灶性CD 26阳性，而在皮肤T细胞淋巴瘤和炎性皮肤病（例如银屑病、扁平苔藓和海绵状皮炎）中，在基底层和棘层中均观察到CD 26表达增加。CD26角质形成细胞染色对单一疾病没有特异性，但似乎与表皮中存在反应性或肿瘤性浸润有关。我们建议，CD26分子可能作为角质形成细胞活化抗原。
CD26 expression on keratinocytes, in both normal and pathological skin, was investigated using immunohistochemical techniques. A sporadic focal CD26 positivity was found in normal skin, whereas increased expression of CD26 was observed both in cutaneous T-cell lymphomas and in inflammatory skin diseases, e.g. psoriasis, lichen planus and spongiotic dermatitis, in the basal and spinous layers. CD26 keratinocyte staining was not specific for a single disease, but seems to be associated with the presence of a reactive or neoplastic infiltrate in the epidermis. We propose that the CD26 molecule may function as a keratinocyte activation antigen.