Influence of Estradiol-Producing Ovarian Tumors on the Maturation Index of Cervical Cytology in Postmenopausal Women
Influence of Estradiol-Producing Ovarian Tumors on the Maturation Index of Cervical Cytology in Postmenopausal Women
复制标题
产雌二醇的卵巢肿瘤对绝经后妇女宫颈细胞学成熟指数的影响
DOI：
10.1159/000524798
复制
发表时间：
2022
期刊：
影响因子：
1.8
通讯作者：
Shozu Makio
中科院分区：
文献类型：
--
作者：
Matsuoka Ayumu;Tate Shinichi;Otsuka Satoyo;Nishikimi Kyoko;Shozu Makio
IntroductionThe aim of the study was to evaluate the impact of estradiol producing ovarian tumors，including surface epithelial-stromal tumors，on the cervical cytology of postmenopausal women.MethodsThis cases-controlled study included 160 postmenopausal women who received a gynecological surgery between January 2009 and December 2016.观察血清雌二醇水平与宫颈细胞学成熟指数的关系。卵巢肿瘤和高雌二醇水平（≥ 28 pg/mL）的患者组成雌二醇产生卵巢肿瘤组（30名女性，包括23名表面上皮间质肿瘤）。将该组的成熟指数与对照组（130名雌二醇水平正常[< 28 pg/mL]的卵巢肿瘤或子宫肿瘤妇女）的成熟指数进行比较。雌二醇阳性卵巢肿瘤组成熟指数（0.67±0.21）明显高于对照组（0.075±0.16）（P< 0.001）。成熟指数的受试者工作特征曲线下面积为0.94。雌二醇分泌卵巢肿瘤的最佳成熟指数截止值为0.20。使用这个截止值，敏感性和特异性分别为94%和82%，respectively. ConclusionEstradiol产生的卵巢肿瘤影响绝经后妇女宫颈上皮成熟。成熟指数的增加可能会触发无症状卵巢肿瘤的早期发现。
IntroductionThe aim of the study was to evaluate the influence of estradiol-producing ovarian tumors, including surface epithelial-stromal tumors, on the cervical cytology of postmenopausal women.MethodsThis case-controlled study included 160 postmenopausal women who underwent a gynecological surgery between January 2009 and December 2016. The relationship between serum estradiol levels and the maturation index of cervical cytology was examined. Patients with ovarian tumors and a high estradiol level (≥ 28 pg/mL) constituted the estradiol-producing ovarian tumor group (30 women, including 23 with surface epithelial-stromal tumors). The maturation index of this group was compared with that of the control group (130 women with normal estradiol levels [< 28 pg/mL] with either ovarian tumors or uterine tumors).ResultsFor all patients, the serum estradiol levels were significantly correlated with the maturation index (p< 0.001, r= 0.65). The maturation index of the estradiol-producing ovarian tumor group was significantly higher than that of the control group (0.67±0.21 vs. 0.075±0.16, p< 0.001). The area under the receiver operating characteristic curve for the maturation index was 0.94. The best maturation index cut-off level for estradiol-producing ovarian tumors was 0.20. Using this cut-off, the sensitivity and specificity were 94% and 82%, respectively.ConclusionEstradiol-producing ovarian tumors influence cervical epithelial maturation in postmenopausal women. An increased maturation index may trigger the early detection of asymptomatic ovarian tumors.