The endoplasmic reticulum: structure, function and response to cellular signaling.
The endoplasmic reticulum: structure, function and response to cellular signaling.
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DOI：
10.1007/s00018-015-2052-6
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发表时间：
2016-01
期刊：
影响因子：
--
通讯作者：
Blower MD
中科院分区：
文献类型：
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作者：
Schwarz DS;Blower MD
内质网（ER）是一个大型的动态结构，在细胞中起许多作用，包括钙储存，蛋白质合成和脂质代谢。ER的不同功能由不同的结构域执行;由小管、片层和核被膜组成。已经鉴定了几种有助于ER的整体结构和动力学的蛋白质，但是关于ER如何响应细胞线索、细胞类型、细胞周期状态和在生物体发育期间改变形状仍然存在许多问题。在这里，我们讨论什么是已知的ER的动态，什么问题仍然存在，以及如何协调的反应添加到这个动态细胞器的监管层。
The endoplasmic reticulum (ER) is a large, dynamic structure that serves many roles in the cell including calcium storage, protein synthesis and lipid metabolism. The diverse functions of the ER are performed by distinct domains; consisting of tubules, sheets and the nuclear envelope. Several proteins that contribute to the overall architecture and dynamics of the ER have been identified, but many questions remain as to how the ER changes shape in response to cellular cues, cell type, cell cycle state and during development of the organism. Here we discuss what is known about the dynamics of the ER, what questions remain, and how coordinated responses add to the layers of regulation in this dynamic organelle.