Hyaluronan biology: A complex balancing act of structure, function, location and context
Hyaluronan biology: A complex balancing act of structure, function, location and context
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DOI：
10.1016/j.matbio.2019.02.002
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发表时间：
2019-05-01
期刊：
影响因子：
6.9
通讯作者：
Savani, Rashmin C.
中科院分区：
文献类型：
--
作者：
Garantziotis, Stavros;Savani, Rashmin C.
细胞-基质相互作用是许多发育、内稳态、免疫和病理过程的基础。透明质酸(HA)是细胞外基质(ECM)的重要组成部分，调节正常的结构完整性和发育，也调节组织在损伤、修复和再生过程中的反应。虽然HA的一级结构很简单，但它以一种高度复杂的方式调节生物反应，它的分子大小和浓度、合成与酶和/或氧化-硝化断裂、与关键的HA结合蛋白和细胞相关受体的相互作用以及它的细胞上下文特定信号都是平衡的贡献。这篇综述强调了决定HA生物活性的不同但相互关联的因素，并介绍了贯穿本期基质生物学关于透明质酸的主要主题。(C)2019爱思唯尔B.V.保留所有权利。
Cell-matrix interactions are fundamental to many developmental, homeostatic, immune and pathologic processes. Hyaluronan (HA), a critical component of the extracellular matrix (ECM) that regulates normal structural integrity and development, also regulates tissue responses during injury, repair, and regeneration. Though simple in its primary structure, HA regulates biological responses in a highly complex manner with balanced contributions from its molecular size and concentration, synthesis versus enzymatic and/or oxidative-nitrative fragmentation, interactions with key HA binding proteins and cell associated receptors, and its cell context-specific signaling. This review highlights the different, but inter-related factors that dictate the biological activity of HA and introduces the overarching themes that weave throughout this special issue of Matrix Biology on hyaluronan. (C) 2019 Elsevier B.V. All rights reserved.