Physiological levels of pro- and anti-inflammatory mediators in cerebrospinal fluid and plasma: A normative study
Physiological levels of pro- and anti-inflammatory mediators in cerebrospinal fluid and plasma: A normative study
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DOI：
10.1089/neu.2005.22.822
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发表时间：
2005-07-01
影响因子：
4.2
通讯作者：
Marzi, I
中科院分区：
文献类型：
--
作者：
Maier, B;Laurer, HL;Marzi, I
最近的许多研究报告了创伤性脑损伤（TBI）、感染或脑肿瘤后大脑和体循环中出现显着的炎症反应，并相继释放促炎和抗炎介质。尽管人们对导致这些患者预后不良的机制有了越来越多的认识和理解，但关于血浆中，特别是脑脊液（CSF）中促炎和抗炎细胞因子和分子的生理表达的数据库却很有限。因此，我们分析了健康人类志愿者的配对血浆/脑脊液样本中白细胞介素 (IL)-6、IL-8、IL-10、可溶性 TNF 受体 (sTNF-R) p55 和 p75、可溶性 ICAM (sICAM) 和可溶性 E-选择素 (sE-选择素) 的生理浓度。在血浆和脑脊液中检测到 IL-6、IL-8、IL-10 以及 sTNF-R p55 和 p75 的生理释放。相反，sICAM 和 sE-选择素仅在血浆中可检测到。促炎介质和抗炎介质在血浆和脑脊液中表现出不同的浓度模式，表明中枢神经系统存在促炎倾向。
Numerous recent studies have reported a significant inflammatory reaction in the brain and the systemic circulation following traumatic brain injury (TBI), infection, or neoplasm of the brain with a sequential release of pro- and anti-inflammatory mediators. Although there is growing knowledge and understanding of the mechanisms leading to the often poor outcome of these patients, only a limited database exists on the physiological expression of pro- and anti-inflammatory cytokines and molecules in plasma and particularly in cerebrospinal fluid (CSF). Therefore, we analyzed paired plasma/CSF samples of healthy human volunteers for the physiological concentrations of Interleukin (IL)-6, IL-8, IL-10, soluble TNF-receptors (sTNF-R) p55 and p75, soluble ICAM (sICAM), and soluble E-selectin (sE-selectin). A physiological release of IL-6, IL-8, IL-10, and sTNF-R p55 and p75 was detected in plasma and CSF. In contrast, sICAM and sE-selectin were only detectable in plasma. Pro- and anti-inflammatory mediators exhibited different concentration patterns in plasma and CSF, suggesting a pro-inflammatory predisposition in the central nervous system.