Altered ultrastructure of lactating rat mammary epithelial cells induced by chronic ethanol ingestion.
Altered ultrastructure of lactating rat mammary epithelial cells induced by chronic ethanol ingestion.
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慢性乙醇摄入诱导哺乳期大鼠乳腺上皮细胞超微结构的改变。
DOI：
10.1111/j.1530-0277.1989.tb00297.x
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
X. Remesar
中科院分区：
文献类型：
--
作者：
S. Vilaró;O. Viñas;X. Remesar
本文研究了哺乳期大鼠乳腺对乙醇和乙醛的摄取及其对乳腺超微结构的影响。慢性和急性乙醇处理后，乙醛的提取量均大于乙醇。长期乙醇管理导致的损失的乳腺细胞极化，在高尔基体dictyosomal元素的减少和酪蛋白的成熟和分泌水平的几个异常，而脂质的合成和分泌似乎没有受到影响。正常的球形酪蛋白胶束呈现出类似凝胶的结构，酪蛋白囊泡融合在一起形成大囊泡。所有这些变化都是乙醇和/或乙醛作用的特异性，而不是由于相关的营养不良，这是从营养对照组中缺乏可见效果推断出来的。
The ethanol and acetaldehyde uptake by the lactating rat mammary gland as well as their effects on this gland at the ultrastructural level have been studied. The extraction of acetaldehyde was greater than that of ethanol both after chronic and acute ethanol treatment. Chronic ethanol administration resulted in a loss of the mammary cell polarization, in a reduction of the Golgi dictyosomal elements and in several abnormalities at the level of casein maturation and secretion, whereas lipid synthesis and secretion did not seem to be affected. Normal spherical casein micelles took on a filament-like structure and casein vesicles appeared fused together forming macrovesicles. All these alterations were specific of ethanol and/or acetaldehyde action and were not due to the associated malnutrition, as deduced from the lack of visible effects in the nutritional control group.