JUNCTIONS IN CENTRAL NERVOUS-SYSTEM OF CAT .1. MEMBRANE-FUSION IN CENTRAL MYELIN
JUNCTIONS IN CENTRAL NERVOUS-SYSTEM OF CAT .1. MEMBRANE-FUSION IN CENTRAL MYELIN
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DOI：
10.1007/bf00221940
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发表时间：
1974-01-01
影响因子：
3.6
通讯作者：
DERMIETZ.R
中科院分区：
文献类型：
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作者：
DERMIETZ.R
用冷冻蚀刻技术对雄性和雌性猫的中央髓鞘进行了研究，并用镧作为示踪剂。髓鞘冷冻断裂和蚀刻的表面显示出在许多方面类似于紧密连接的膜形成。形成层由一半膜上的平行颗粒排组成，另一半膜上的相应沟槽匹配。这些结构横跨髓鞘的宽度，最常见的是位于外胞浆环下方的髓鞘部分。它们被解释为高锰酸钾染色后出现在中央髓鞘横断面上的I线的径向成分的相关性。在结旁区域，少突胶质细胞膜的外部小叶之间可见点状融合的富含镧的髓鞘。这些发现有力地表明，紧密连接是中央髓鞘的一个共同特征。讨论了膜融合与板层复合体元素的排列及其功能意义。
In male and female cats central myelin was studied using the freeze-etching technique, and after impregnation with lanthanum as a tracer. The freeze-fractured and etched faces of the myelin reveal membrane formations which in many respects resemble tight junctions. The formations consist of parallel rows of particles on one half of the membranes matched by corresponding furrows on the other membrane half. These structures occur across the width of the myelin sheath and are most common in that part of the myelin underlying the external cytoplasmic loop. They are interpreted as correlates of the radial component of the i-line which occurs in cross-sections of central myelin after potassium permanganate staining. In the paranodal zone the lanthanum-impregnated myelin displays punctate fusions between the outer leaflets of the oligodendrocytic membranes. These findings strongly suggest that tight junctions are a common feature in the central myelin. The arrangement of the membrane fusion in relation to the elements of the lamellar complex and their functional significance is discussed.