Experimental verification and theoretical prediction of cartilage interstitial fluid pressurization at an impermeable contact interface in confined compression
Experimental verification and theoretical prediction of cartilage interstitial fluid pressurization at an impermeable contact interface in confined compression
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DOI：
10.1016/s0021-9290(98)00105-5
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发表时间：
1998-10-01
影响因子：
2.4
通讯作者：
Ateshian, GA
中科院分区：
文献类型：
--
作者：
Soltz, MA;Ateshian, GA
长期以来，人们一直假设间质液加压在关节软骨的负载支撑机制和摩擦响应中起着重要作用。然而，迄今为止，很少有实验研究通过直接测量来验证这一假设。本研究的第一个目的是通过实验研究软骨间质流体加压在受限压缩蠕变和应力松弛的测试配置中确实支持绝大多数施加载荷的假设。第二个目的是研究这样一个假设，即实验观察到的间质流体增压也可以用Mow等人的线性双相理论来预测。[j] .机械工程学报，2009,33(2):481 - 481。14个牛软骨样品在一个装有微芯片压阻式传感器的密闭压缩室中进行测试，以测量间隙流体压力，同时测量（应力松弛期间）或规定（蠕变期间）总应力。结果发现，在应力松弛期间，间质流体压力支撑了超过90%的总应力，持续时间长达725 +/- 248 s（平均+/- sd = 7），蠕变期间为404 +/- 229 s。将随时间变化的间隙流体压力的实验测量值与线性双相理论的预测值进行比较，发现非线性决定系数r(2) = 0.871 +/- 0.086（应力松弛）和r(2) = 0.941 +/- 0.061（蠕变）。本研究的结果提供了一些迄今为止最直接的证据，表明间质流体加压在软骨力学中起着基本作用；这也表明，从理论上可以很好地预测软骨中流体负载支撑的机制。1998爱思唯尔科学有限公司版权所有。
Interstitial fluid pressurization has long been hypothesized to play a fundamental role in the load support mechanism and frictional response of articular cartilage. However, to date, few experimental studies have been performed to verify this hypothesis from direct measurements. The first objective of this study was to investigate experimentally the hypothesis that cartilage interstitial fluid pressurization does support the great majority of the applied load, in the testing configurations of confined compression creep and stress relaxation. The second objective was to investigate the hypothesis that the experimentally observed interstitial fluid pressurization could also be predicted using the linear biphasic theory of Mow et al. (J. Biomech. Engng ASME, 102, 73-84, 1980). Fourteen bovine cartilage samples were tested in a confined compression chamber fitted with a microchip piezoresistive transducer to measure interstitial fluid pressure, while simultaneously measuring (during stress relaxation) or prescribing (during creep) the total stress. It was found that interstitial fluid pressure supported more than 90% of the total stress for durations as long as 725 +/- 248 s during stress relaxation (mean +/- S.D., it = 7), and 404 +/- 229 s during creep tit = 7). When comparing experimental measurements of the time varying interstitial fluid pressure against predictions from the linear biphasic theory, nonlinear coefficients of determination r(2) = 0.871 +/- 0.086 (stress relaxation) and r(2) = 0.941 +/- 0.061 (creep) were found. The results of this study provide some of the most direct evidence to date that interstitial fluid pressurization plays a fundamental role in cartilage mechanics; they also indicate that the mechanism of fluid load support in cartilage can be properly predicted from theory. (C) 1998 Elsevier Science Ltd. All rights reserved.