Capsaicin evoked pain and allodynia in post-herpetic neuralgia
Capsaicin evoked pain and allodynia in post-herpetic neuralgia
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DOI：
10.1016/s0304-3959(00)00311-0
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发表时间：
2000-11-01
期刊：
影响因子：
7.4
通讯作者：
Rowbotham, MC
中科院分区：
文献类型：
--
作者：
Petersen, KL;Fields, HL;Rowbotham, MC
在17例带状疱疹后神经痛（PHN）患者中，研究了保留的初级传入伤害感受器的输入和中枢疼痛传递神经元的敏化相结合维持与PHN相关的疼痛和异常性疼痛的假设。疼痛，异常性疼痛，热感觉功能，皮肤神经支配，并控制应用0.075%辣椒素的反应进行了测量。与镜像皮肤相比，在9 cm（2）面积的PHN皮肤上应用辣椒素显著增加了17名受试者中11名的总体PHN疼痛和异常性疼痛。这些“辣椒素反应者”的特征是与无反应者相比，平均每日疼痛更高，异常性疼痛评分更高，基线时感觉功能相对保留。在三个“辣椒素反应者”中，异常性疼痛的区域扩展到以前无异常性疼痛和无疼痛的皮肤，这些皮肤具有正常的感觉功能和皮肤神经支配。这些观察结果支持这一假设，即在一些PHN患者的异常性疼痛是一种形式的慢性继发性痛觉过敏维持输入从完整的，可能是“易激”的初级传入伤害感受器致敏的CNS。(C)2000年国际疼痛研究协会。由Elsevier Science B.V.出版，版权所有。
The hypothesis that the pain and allodynia associated with post-herpetic neuralgia (PHN) is maintained by a combination of input from preserved primary afferent nociceptors and sensitization of central pain transmitting neurons was examined in 17 subjects with PHN. Pain, allodynia, thermal sensory function, cutaneous innervation, and response to controlled application of 0.075% capsaicin were measured. Compared to mirror-image skin, applying capsaicin on a 9 cm(2) area of PHN skin significantly increased overall PHN pain and allodynia in 11 of 17 subjects. These 'capsaicin responders' were characterized by higher average daily pain, higher allodynia ratings, and relatively preserved sensory function at baseline compared to the non-responders. In three of the 'capsaicin responders' the area of allodynia expanded into previously non-allodynic and non-painful skin that had normal sensory function and cutaneous innervation. These observations support the hypothesis that allodynia in some PHN patients is a form of chronic secondary hyperalgesia maintained by input from intact and possibly 'irritable' primary afferent nociceptors to a sensitized CNS. (C) 2000 International Association for the Study of Pain. Published by Elsevier Science B.V. All rights reserved.