Prevalence and specificities of red cell alloantibodies among blood recipients in the Malaysian state of Kelantan
Prevalence and specificities of red cell alloantibodies among blood recipients in the Malaysian state of Kelantan
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马来西亚吉兰丹州受血者红细胞同种抗体的患病率和特异性
DOI：
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发表时间：
2011
影响因子：
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通讯作者：
Mohd Ismail
中科院分区：
文献类型：
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作者：
F. Al;Anuar Bin Ali;Majdan Ramli;S. Ahmed;Mohd Ismail
背景：红细胞(RBC)抗原暴露后可形成同种异体抗体。在大多数情况下，同种异体免疫是在怀孕期间或从以前的输血中发展起来的。红细胞抗原及其同种异体抗体在不同人群和不同种族之间存在差异，对其不良免疫反应具有一定的临床意义。目的：本研究旨在研究马来西亚哥打巴鲁Raja Perempuan Zainab II医院输血科RBC同种异体抗体的流行情况。患者和方法：利用2007年和2008年获得的数据进行了一项横断面研究。对5719例患者的抗体筛查结果进行了分析。结果和讨论：同种异体免疫的总患病率为65(1.13%)。其中大多数人只有一种同种异体抗体(76.9%)，而其余的23.1%有多种抗体。抗E抗体是最常见的同种异体抗体(24.6%)，其次是抗Lewis(A)抗体(18.5%)和抗M抗体(13.8%)。女性受者比男性多。结论：这项工作的结果与其他已发表的研究结果具有可比性，与同种异体抗体形成相关的主要因素是多次输血和怀孕。该研究还强调了在每次输血前进行免疫血液学检查的必要性，特别是在需要长时间多次输血的情况下，如地中海贫血患者。
Background: Red blood cell (RBC) alloantibodies may be formed following exposure to RBC antigens. In most cases, the alloimmunization develops during pregnancy or from previous blood transfusions. The RBC antigens and their alloantibodies vary among different human populations and ethnic groups, and they do have a clinical significance for their adverse immunological reactions. Aims: This study aimed at studying the prevalence of RBC alloantibodies at the Blood Transfusion Unit of Hospital Raja Perempuan Zainab II in Kota Bharu, Malaysia. Patients and Methods: A cross-sectional study was performed utilizing data obtained in the years 2007 and 2008. Data of antibody screening tests from 5719 patients were examined. Results and Discussion: The overall prevalence of alloimmunization was 65 (1.13%). The majority of these had a single alloantibody (76.9%), whereas the remaining 23.1% had multiple antibodies. The anti-E antibody comprised the most common alloantibody (24.6%) followed by the anti-Lewis (a) antibodies (18.5%) and the anti-M antibody (13.8%). There were more female recipients than males. Conclusions: It was concluded that the findings of this work have been comparable with other published works, and that the main factors associated with alloantibody formation were multiple transfusions and pregnancies. The study also emphasizes the necessity for carrying out immunohematology studies prior to every blood transfusion especially in cases that require multiple transfusions for a long period of time such as in thalassemia patients.