Regulatory immune cells in regulation of intestinal inflammatory response to microbiota.
Regulatory immune cells in regulation of intestinal inflammatory response to microbiota.
复制标题
调节性免疫细胞调节肠道对微生物群的炎症反应
DOI：
10.1038/mi.2015.49
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发表时间：
2015-09
影响因子：
8
通讯作者：
Liu Z
中科院分区：
文献类型：
--
作者：
Sun M;He C;Cong Y;Liu Z
肠腔内有近 100 万亿个共生细菌，它们对健康发挥着至关重要的作用。维持肠道稳态需要免疫反应和对肠道微生物群的耐受性之间的精心平衡。这个过程取决于多种调节机制，包括先天免疫和适应性免疫。肠道免疫系统和微生物群之间的稳态失调已被证明与遗传易感人群中炎症性肠病（IBD）的发生有关。在这篇综述中，我们讨论了肠道中不同类型的调节性免疫细胞研究的最新进展，包括肠上皮内淋巴细胞、Foxp3+调节性T细胞、调节性B细胞、替代性激活的巨噬细胞、树突状细胞和先天性淋巴细胞，以及这种免疫调节系统的功能障碍如何导致IBD等肠道疾病。此外，我们讨论了操纵这些调节性免疫细胞作为治疗肠道炎症性疾病的潜在治疗方法。
The intestinal lumen harbors nearly 100 trillion commensal bacteria that exert crucial function for health. An elaborate balance between immune responses and tolerance to intestinal microbiota is required to maintain intestinal homeostasis. This process depends on diverse regulatory mechanisms, including both innate and adaptive immunity. Dysregulation of the homeostasis between intestinal immune systems and microbiota has been shown to be associated with the development of inflammatory bowel diseases (IBD) in genetically susceptible populations. In this review, we discuss the recent progress reported in studies of distinct types of regulatory immune cells in the gut, including intestinal intraepithelial lymphocytes, Foxp3+ regulatory T cells, regulatory B cells, alternatively activated macrophages, dendritic cells, and innate lymphoid cells, and how dysfunction of this immune regulatory system contributes to intestinal diseases such as IBD. Moreover, we discuss the manipulation of these regulatory immune cells as a potential therapeutic method for management of intestinal inflammatory disorders.