Budding dynamics of individual domains in multicomponent membranes simulated by N-varied dissipative particle dynamics
Budding dynamics of individual domains in multicomponent membranes simulated by N-varied dissipative particle dynamics
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DOI：
10.1021/jp066046h
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发表时间：
2007-05-31
影响因子：
3.3
通讯作者：
Yang, Yuliang
中科院分区：
文献类型：
--
作者：
Hong, Bingbing;Qiu, Feng;Yang, Yuliang
我们研究了在平坦的，多组分膜中使用耗散粒子动力学（DPD）模拟与不同的珠数N，其中添加和删除的珠的基础上，他们的密度在膜边界的萌芽动力学。本文研究了管状芽的出芽过程，并从能量和形态两个方面分析了这一过程的动力学转变。模拟结果表明，出芽持续时间缩短线张力的增加，并依赖于域的大小平方。在低线张力下，增加弯曲模量首先加速出芽，但随着其进一步增加而抑制该过程。此外，还探讨了表面张力在出芽过程中的控制作用。最后，我们使用N-变化的DPD来模拟实验观察到的多组分管状囊泡，并证实了三种芽生长模式。
We study the budding dynamics of individual domains in flat, multicomponent membranes using dissipative particle dynamics (DPD) simulations with varied bead number N, in which addition and deletion of beads based on their density at the membrane boundary is introduced. The budding process of a tubular bud, accompanied by a dynamical transition reflected in the energy and morphology evolutions, is investigated. The simulations show that budding duration is shortened with increasing line tension and depends on the domain size quadratically. At low line tension, increasing bending modulus accelerates budding at first, but suppresses the process as it increases further. In addition, the controlling role of the surface tension in the budding process is also explored. Finally, we use the N-varied DPD to simulate the experimentally observed multicomponent tubular vesicles, and the three bud growth modes are confirmed.