Characterisation of anti-Staphylococcus aureus activity of quercetin
Characterisation of anti-Staphylococcus aureus activity of quercetin
复制标题
DOI：
10.1111/j.1365-2621.2010.02267.x
复制
发表时间：
2010-06-01
影响因子：
3.3
通讯作者：
Yamamoto, Yoshimasa
中科院分区：
文献类型：
--
作者：
Hirai, Itaru;Okuno, Mana;Yamamoto, Yoshimasa
虽然许多抗生素可用于治疗细菌感染，但耐药性细菌的出现和全球传播是一个全社会的问题。为了解决这个问题，我们必须探索替代抗菌剂。这项研究调查了蔬菜和水果中存在的一种黄酮类化合物槲皮素的抗菌特性。槲皮素对革兰氏阳性菌和革兰氏阴性菌进行了测试，发现其对金黄色葡萄球菌（包括耐甲氧西林的金黄色葡萄球菌）具有选择性抗菌活性。金黄色葡萄球菌（MRSA）和表皮葡萄球菌。一些临床MRSA菌株对槲皮素表现出显著的敏感性。与抗生素如苯唑西林、氨苄西林、万古霉素、庆大霉素和红霉素组合，槲皮素显示出对MRSA的显著增强的抗菌活性。我们还报道了槲皮素诱导的S.金黄色葡萄球菌细胞;这些细胞的形态学变化，如通过电子显微镜评估的;和槲皮素敏感的MRSA的集落扩散能力，所有这些都揭示了槲皮素对S.金黄色。
P>Although many antibiotics are available for the treatment of bacterial infections, the emergence and global spread of antibiotic-resistant bacteria is a community-wide problem. To overcome this problem, we must explore alternative antimicrobials. This study investigated the antibacterial properties of quercetin, a flavonoid present in vegetables and fruits. Quercetin was tested against gram-positive and gram-negative bacteria and was found to exert selective antibacterial activity against Staphylococcus aureus, including methicillin-resistant S. aureus (MRSA), and Staphylococcus epidermidis. Some clinical MRSA strains showed remarkable susceptibility to quercetin. In combination with antibiotics, such as oxacillin, ampicillin, vancomycin, gentamicin, and erythromycin, quercetin showed markedly enhanced antibacterial activity against MRSA. We also report quercetin-induced aggregation of S. aureus cells; the morphological changes in these cells, as assessed by electron microscopy; and the colony-spreading ability of quercetin-sensitive MRSA, all of which revealed the unique antibacterial properties of quercetin against S. aureus.