The role of HER2 in early breast cancer metastasis and the origins of resistance to HER2-targeted therapies.
The role of HER2 in early breast cancer metastasis and the origins of resistance to HER2-targeted therapies.
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DOI：
10.1016/j.yexmp.2009.05.001
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发表时间：
2009-08
影响因子：
3.6
通讯作者：
Greene, Mark I.
中科院分区：
文献类型：
--
作者：
Freudenberg, Jaclyn A.;Wang, Qiang;Katsumata, Makoto;Drebin, Jeffrey;Nagatomo, Izumi;Greene, Mark I.
HER 2基因编码受体酪氨酸激酶HER 2，并且通常在乳腺癌中过度表达或扩增。HER 2的上调有助于肿瘤进展。肿瘤生长的许多方面通过HER 2信号传导的激活而受到有利影响。事实上，HER 2在增加原发性肿瘤和远端病变的增殖和存活中起作用，所述原发性肿瘤和远端病变在完成完全转化后引起转移。P185 HER 2/neu受体和来自它们的信号传导以及相关分子导致增加内渗和外渗细胞的运动性、减少凋亡、增强与微环境的信号传导相互作用、调节粘附以及许多其他功能。最近的实验和临床证据支持这样的观点，即不完全转化细胞的扩散发生在肿瘤进展的非常早期阶段。本文综述了HER 2的识别和表征，转移模型的演变，以及最近的癌症干细胞模型。特别是，我们审查了HER 2+乳腺癌进展的新机制的证据，即未转化的HER 2表达细胞显示干/祖细胞的特征，转移，然后在第二位点完成其最终转化。
The HER2 gene encodes the receptor tyrosine kinase HER2 and is often over-expressed or amplified in breast cancer. Up-regulation of HER2 contributes to tumor progression. Many aspects of tumor growth are favorably affected through activation of HER2 signaling. Indeed, HER2 plays a role in increasing proliferation and survival of the primary tumor and distant lesions which upon completion of full transformation cause metastases. P185HER2/neu receptors and signaling from them and associated molecules lead to increase motility of both intravasating and extravasating cells, decreasing apoptosis, enhancing signaling interactions with the microenvironment, regulating adhesion, as well as a multitude of other functions. Recent experimental and clinical evidence supports the view that spread of incompletely transformed cells occurs at a very early stage in tumor progression. This review concerns the identification and characterization of HER2, the evolution of the metastasis model, and the more recent cancer stem cell model. In particular, we review the evidence for an emerging mechanism of HER2+ breast cancer progression, whereby the untransformed HER2-expressing cell shows characteristics of stem/progenitor cell, metastasizes, and then completes its final transformation at the secondary site.
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影响因子：
50.3
作者：
Agus, DB;Akita, RW;Sliwkowski, MX
通讯作者：
Sliwkowski, MX
影响因子：
3.8
作者：
Cameron, David;Casey, Michelle;Geyer, Charles E.
通讯作者：
Geyer, Charles E.
影响因子：
11.2
作者：
Aguirre-Ghiso, JA;Ossowski, L;Rosenbaum, SK
通讯作者：
Rosenbaum, SK
影响因子：
11.5
作者：
Balic, Marija;Lin, Henry;Cote, Richard J.
通讯作者：
Cote, Richard J.
影响因子：
21.3
作者：
Aranda, Victoria;Haire, Teresa;Muthuswamy, Senthil K.
通讯作者：
Muthuswamy, Senthil K.