Chronic infection with hepatitis C virus in patients with elevated or persistently normal serum alanine aminotransferase levels: comparison of hepatic histology and response to interferon therapy.
Chronic infection with hepatitis C virus in patients with elevated or persistently normal serum alanine aminotransferase levels: comparison of hepatic histology and response to interferon therapy.
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血清丙氨酸氨基转移酶水平升高或持续正常的患者慢性丙型肝炎病毒感染：肝组织学和干扰素治疗反应的比较。
DOI：
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发表时间：
2000
影响因子：
6.4
通讯作者：
A. Sanyal
中科院分区：
文献类型：
--
作者：
M. Shiffman;C. Stewart;C. Hofmann;M. Contos;V. Luketic;R. Sterling;A. Sanyal
95例慢性丙型肝炎病毒（HCV）感染患者，其中35例血清丙氨酸氨基转移酶（ALT）持续正常，随机分为干扰素（IFN）治疗组（A组）和干扰素治疗组（B组）。ALT水平升高的患者与ALT水平正常的患者具有相似的人口统计学和病毒学特征，但显著（P<0.05）更晚期的肝组织学（桥接纤维化和肝硬化，37.9%对11.4%）。治疗3个月后，A组HCVRNA转阴率为38.3%，而B组为18.8%（P<0.05）。当IFN剂量从每日减少到TIW时，A组中保持HCV RNA阴性的患者百分比下降;两组中持续病毒学应答相似（10.6% vs. 8.3%）。ALT水平升高或正常的患者对治疗的反应相似。慢性HCV感染和持续正常血清ALT水平的人比ALT水平升高的人有更轻的肝病，并且对IFN治疗的反应与ALT水平升高的人相似。
Ninety-five patients with chronic hepatitis C virus (HCV) infection, 35 with persistently normal serum alanine aminotransferase (ALT) levels, were randomized to treatment with daily interferon (IFN) for 3 months, followed by IFN 3 times weekly (TIW) for 12 months (group A) or TIW for 18 months (group B). Patients with elevated versus normal ALT levels had similar demographic and virologic characteristics but significantly (P<.05) more advanced liver histology (bridging fibrosis and cirrhosis, 37.9% vs. 11.4%). After 3 months of treatment, 38.3% of patients in group A were HCV RNA negative versus 18.8% in group B (P<.05). When the IFN dose was reduced from daily to TIW in group A, the percentage of patients who remained HCV RNA negative declined; sustained virologic response was similar in both groups (10.6% vs. 8.3%). Response to treatment was similar in patients with elevated or normal ALT levels. Persons with chronic HCV infection and persistently normal serum ALT levels have milder liver disease than, and respond to IFN therapy similarly to, persons with elevated ALT levels.
影响因子：
158.5
作者：
McHutchison, JG;Gordon, SC;Albrecht, JK
通讯作者：
Albrecht, JK
使用大剂量干扰素治疗慢性丙型肝炎。
DOI：
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发表时间：
1999
期刊：
Seminars in liver disease.
影响因子：
--
作者：
Shiffman,ML
通讯作者：
Shiffman,ML
慢性丙型肝炎转氨酶与肝脏组织学状态的关系。
DOI：
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发表时间：
1995
期刊：
The American journal of gastroenterology.
影响因子：
--
作者：
Haber,MM;West,AB;Haber,AD;Reuben,A
通讯作者：
Reuben,A