Electrocorticographic decoding of ipsilateral reach in the setting of contralateral arm weakness from a cortical lesion.
Electrocorticographic decoding of ipsilateral reach in the setting of contralateral arm weakness from a cortical lesion.
复制标题
在皮质病变导致对侧手臂无力的情况下，对同侧伸展进行皮质电图解码。
DOI：
10.1109/embc.2012.6346869
复制
发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Crone,NathanE
中科院分区：
文献类型：
--
作者：
Hotson,Guy;Fifer,MatthewS;Acharya,Soumyadipta;Anderson,WilliamS;Thakor,NitishV;Crone,NathanE
脑机接口具有恢复运动功能的潜力，不仅适用于脊髓和外周神经传出通路截肢或病变的患者，而且适用于获得性脑病变（如中风和肿瘤）的患者。在这些患者中，皮质运动系统中最有效的成分不能用于BMI控制。在这里，我们有机会调查的可能性，利用硬膜下皮层电图（ECoG）信号来控制自然达到运动在这些情况下。在一例复发性胶质瘤切除术后出现左臂单瘫的受试者中，我们发现记录在剩余皮质中的ECoG信号足以解码非麻痹手臂的自然伸展运动的运动学，同侧ECoG记录。受试者的ECoG信号和三维中的到达轨迹之间的关系，其中两个高度相关，用计算简单的线性模型捕获（深度维度的平均Pearson r = 0.68，高度= 0.73，横向= 0.24）。这些结果仅用7个时间/频谱神经信号特征的一个小子集来实现。获得高解码结果所需的神经功能的小子集显示出仅由同侧ECoG信号控制的恢复性BMI的希望。
Brain machine interfaces have the potential for restoring motor function not only in patients with amputations or lesions of efferent pathways in the spinal cord and peripheral nerves, but also patients with acquired brain lesions such as strokes and tumors. In these patients the most efficient components of cortical motor systems are not available for BMI control. Here we had the opportunity to investigate the possibility of utilizing subdural electrocorticographic (ECoG) signals to control natural reaching movements under these circumstances. In a subject with a left arm monoparesis following resection of a recurrent glioma, we found that ECoG signals recorded in remaining cortex were sufficient for decoding kinematics of natural reach movements of the nonparetic arm, ipsilateral to the ECoG recordings. The relationship between the subject's ECoG signals and reach trajectory in three dimensions, two of which were highly correlated, was captured with a computationally simple linear model (mean Pearson's r in depth dimension= 0.68, in height= 0.73, in lateral= 0.24). These results were attained with only a small subset of 7 temporal/spectral neural signal features. The small subset of neural features necessary to attain high decoding results show promise for a restorative BMI controlled solely by ipsilateral ECoG signals.