Somatic aging pathways regulate reproductive plasticity in Caenorhabditis elegans.
Somatic aging pathways regulate reproductive plasticity in Caenorhabditis elegans.
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DOI：
10.7554/elife.61459
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发表时间：
2021-07-08
期刊：
影响因子：
7.7
通讯作者：
Hall SE
中科院分区：
文献类型：
--
作者：
Ow MC;Nichitean AM;Hall SE
在动物中，早期生活压力可能导致基因表达的程序性变化，从而影响其成年表型。In C.线虫，饥饿在第一幼虫阶段促进进入抗应激的幼虫阶段，直到环境条件改善。经历过dauer（postdauer）的成年人保留着早期饥饿的记忆，导致基因表达变化和繁殖力下降。在这里，我们表明，内分泌途径归因于调节体细胞衰老在C。缺乏功能性种系的秀丽线虫成虫也调节经历过早期饥饿的波斯特道尔成虫的生殖表型。我们证明，postdauer成人重新分配脂肪，以有利于后代在牺牲父母的体细胞脂肪库，并表现出增加寿命相比，控制。我们的研究结果还表明，由于亲本饥饿记忆的体细胞脂肪储存的修改是遗传在F1代，可能是由生殖细胞核RNAi途径介导的体细胞和生殖组织之间的串扰的结果。
In animals, early-life stress can result in programmed changes in gene expression that can affect their adult phenotype. In C. elegans nematodes, starvation during the first larval stage promotes entry into a stress-resistant dauer stage until environmental conditions improve. Adults that have experienced dauer (postdauers) retain a memory of early-life starvation that results in gene expression changes and reduced fecundity. Here, we show that the endocrine pathways attributed to the regulation of somatic aging in C. elegans adults lacking a functional germline also regulate the reproductive phenotypes of postdauer adults that experienced early-life starvation. We demonstrate that postdauer adults reallocate fat to benefit progeny at the expense of the parental somatic fat reservoir and exhibit increased longevity compared to controls. Our results also show that the modification of somatic fat stores due to parental starvation memory is inherited in the F1 generation and may be the result of crosstalk between somatic and reproductive tissues mediated by the germline nuclear RNAi pathway.