Water-pipe smoking effects on pulmonary permeability using technetium-99m DTPA inhalation scintigraphy
Water-pipe smoking effects on pulmonary permeability using technetium-99m DTPA inhalation scintigraphy
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DOI：
10.1007/bf02984465
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发表时间：
2004-06-01
影响因子：
2.6
通讯作者：
Ceylan, E
中科院分区：
文献类型：
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作者：
Aydin, A;Kiter, G;Ceylan, E
目的：虽然人们已经对吸烟及其对肺功能的影响进行了大量的研究，但对水烟的研究数量有限。水烟对健康的影响还没有得到广泛的研究。本研究的目的是确定水烟对肺通透性的影响。研究方法：对14名水管吸烟志愿者（均为男性，平均年龄53.7 ± 9.8岁）和11名被动吸烟志愿者（1名女性，10名男性，平均年龄43.8 ± 12岁）进行了锝-99mDTPA吸入放射性造影。通过对时间活性曲线进行单指数拟合计算清除半衰期（T1/2）。还计算了放射性气溶胶的渗透指数（PI）。结果：水管吸烟者（WPS）和被动吸烟者（PS）的PI分别为0.58 ± 0.14和0.50 ± 0.12。WPS和PS的外周肺T1/2分别为57.3 +/-12.7和64.6 +/-13.2 min，中心气道分别为55.8 +/-23.5和80.1 +/-35.2 min（p ≤ 0.05）。WPS和PS的FEV1/FVC %分别为82.1 +/-8.5（%）和87.7 +/-6.5（%）（0.025 <p小于或等于0.05）。结论：我们认为水烟袋吸烟比被动吸烟对肺上皮细胞通透性的影响更大。在水烟中增加的中央粘膜纤毛清除可能是由于气道保持湿度。
Objective: Although extensive work has been done on cigarette smoking and its effects on pulmonary function, there are limited number of studies on water-pipe smoking. The effects of water-pipe smoking on health are not widely investigated. The aim of this study was to determine the effects of water-pipe smoking on pulmonary permeability. Methods: Technetium-99m DTPA inhalation scintigraphy was performed on 14 water-pipe smoker volunteers (all men, mean age 53.7 +/- 9.8) and 11 passive smoker volunteers (1 woman, 10 men, mean age 43.8 +/- 12). Clearance half-time (T 1/2) was calculated by placing a monoexponential fit on the time activity curves. Penetration index (PI) of the radioaerosol was also calculated. Results: PI was 0.58 +/- 0.14 and 0.50 +/- 0.12 for water-pipe smokers (WPS) and passive smokers (PS) respectively. T 1/2 of peripheral lung was 57.3 +/- 12.7 and 64.6 +/- 13.2 min, central airways was 55.8 +/- 23.5 and 80.1 +/- 35.2 min for WPS and PS, respectively (p less than or equal to 0.05). FEV1/FVC% was 82.1 +/- 8.5 (%) and 87.7 +/- 6.5 (%) for WPS and PS, respectively (0.025 < p less than or equal to 0.05). Conclusions: We suggest that water-pipe smoking effects pulmonary epithelial permeability more than passive smoking. Increased central mucociliary clearance in water-pipe smoking may be due to preserved humidity of the airway tracts.