Exercise intervention as a protective modulator against metabolic disorders in cigarette smokers
Exercise intervention as a protective modulator against metabolic disorders in cigarette smokers
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DOI：
10.1589/jpts.28.983
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发表时间：
2016-03-01
影响因子：
--
通讯作者：
Iqbal, Zaheen A.
中科院分区：
文献类型：
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作者：
Al-Eisa, Einas;Alghadir, Ahmad H.;Iqbal, Zaheen A.
[目的]评价运动强度对吸烟欲望、血清可替宁、应激激素、总抗氧化能力和氧化自由基作为心肺代谢紊乱潜在标志物的影响。在吸烟者中。[对象与方法]随机选择150名健康男性，年龄18-55岁，分为4组：对照组（不吸烟者，N= 30）、轻度吸烟组（N = 33）、中度吸烟组（N = 42）和重度吸烟组（N = 45）。参与者被分配到中等（8周）或短期（20-45分钟）运动训练。吸烟欲望，情绪和身体症状量表，主观运动经历量表评分，可替宁，应激激素（皮质醇和睾酮），自由基（丙二醛，一氧化氮），和总抗氧化能力进行了评价。[结果]所有吸烟组的血清可替宁、皮质醇、睾酮、一氧化氮和丙二醛水平均显著升高，总抗氧化能力活性降低;重度吸烟组代谢产物的变化更大。在所有吸烟者组中，短强度和中等强度运动均显著降低可替宁、皮质醇、睾酮和丙二醛，并增加一氧化氮水平和总抗氧化能力活性;此外，吸烟欲望、情绪和身体症状量表以及主观运动经历量表评分均降低。这支持了运动增加一氧化氮生物利用度，增强血管功能并最终降低心肺疾病发生率的能力。[结论]不同强度的运动干预可作为尼古丁替代治疗或预防吸烟相关心肺功能障碍的辅助手段。
[Purpose] assess the impact of exercise intensity on desire to smoke, serum cotinine, stress hormones, total antioxidant capacity, and oxidative free radicals as potential markers of cardiopulmonary metabolic disorders were measured. in cigarette smokers. [Subjects and Methods] The participants (150 randomly selected healthy men, aged 18-55 years) were classified into 4 smoking groups: control (non-smokers; N= 30); mild (N = 33); moderate (N = 42), and heavy (N = 45). The participants were assigned to either moderate (8 weeks) or short-term (20-45 min) exercise training. The desire to smoke, Mood and Physical Symptoms Scale, and Subjective Exercise Experiences Scale scores, cotinine, stress hormones (cortisol and testosterone), free radicals (malondialdehyde, nitric oxide), and total antioxidant capacity were evaluated. [Results] Significant increases in serum cotinine, cortisol, testosterone, nitric oxide, and malondialdehyde levels and a reduction in total antioxidant capacity activity were observed in all smoker groups; heavy smokers showed a higher change in metabolites. In all smoker groups, both short and moderate- intensity exercises significantly reduce cotinine, cortisol, testosterone, and malondialdehyde and increased nitric oxide levels and total antioxidant capacity activity; further, the desire to smoke, Mood and Physical Symptoms Scale, and Subjective Exercise Experiences Scale scores were reduced. This supports the ability of exercise to increase nitric oxide bioavailability, enhance of blood vessels function and ultimately decrease the incidence of cardiopulmonary disorders. [Conclusion] Exercise interventions with varying intensities may be used as nicotine replacement therapy or protective aids against smoking-related cardiopulmonary disorders.