Renal cell carcinoma in relation to cigarette smoking: Meta-analysis of 24 studies
Renal cell carcinoma in relation to cigarette smoking: Meta-analysis of 24 studies
复制标题
DOI：
10.1002/ijc.20618
复制
发表时间：
2005-03-10
影响因子：
6.4
通讯作者：
Brennan, P
中科院分区：
文献类型：
--
作者：
Hunt, JD;van der Hel, OL;Brennan, P
肾细胞癌（RCC）占成人癌症死亡的3%。其发展的风险因素仍在紧张调查中。虽然吸烟是一个风险因素，但数据不一致，风险增加的程度也不清楚。使用了19项病例对照研究和5项队列研究的估计值。病例对照报告包括8，032例病例和13，800例对照：队列估计基于1，457，754名参与者和1，326例RCC病例。与终生不吸烟者相比，吸烟者患肾细胞癌的相对危险度（RR）为1.38（95%置信区间[CI] = 1.27-1.50）。男性吸烟者的RR为1.54（95%CI = 1.42-1.68），女性吸烟者为1.22（95%CI = 1.09-1.36）。对于男性和女性来说，风险有很强的剂量依赖性增加。每天吸烟1-9支、10-20支或21支或更多支的男性吸烟者的RR分别为1.60（95% CI = 1.21-2.12）、1.83（95% CI = 1.30-2.57）或2.03（95% CI = 1.51-2.74）。对于女性，相对危险度分别为0.98（95%CI = 0.71-1.35）、1.38（95%CI = 0.90 - 2.11）或1.58（95%CI = 1.14-2.20）。与戒烟1-10年的人相比，戒烟>10年的人的RR降低证实了戒烟的优势。吸入烟草烟雾显然与RCC的病因有关，与每天吸烟数量相关的风险呈强烈的剂量依赖性增加，长期吸烟者的风险大幅降低。(C)2004年威利-利斯。Inc.
Renal cell carcinoma (RCC) accounts for 3% of adult deaths from cancer. The risk factors for its development are still under intense investigation. Although tobacco smoke is a risk factor, the data are inconsistent and the extent of the increased risk is unclear. Estimates from 19 case-control and 5 cohort studies were used. The case-control reports included 8,032 cases and 13,800 controls: the cohort estimates were based on 1,457,754 participants with 1,326 cases of RCC. The relative risk (RR) for RCC for ever smokers as compared to lifetime never smokers was 1.38 (95% confidence interval [CI] = 1.27-1.50). The RR for male smokers was 1.54 (95 % CI = 1.42-1.68) and for female smokers was 1.22 (95 % Cl = 1.09-1.36). For men and women there was a strong dose-dependent increase in risk. Ever smoker men who had smoked 1-9, 10-20 or 21 or more cigarettes/day had a RR of 1.60 (95% CI = 1.21-2.12), 1.83 (95% CI = 1.30-2.57), or 2.03 (95% Cl = 1.51-2.74), respectively. For women, the relative risks were 0.98 (95% CI = 0.71-1.35), 1.38 (95 % CI = 0.90 -2.11), or 1.58 (95 % CI = 1.14-2.20), respectively. The advantages of smoking cessation were confirmed by a reduction in RR for those who had quit smoking for >10 years as compared to those who had quit for 1-10 years. Inhaled tobacco smoke is clearly implicated in the etiology of RCC, with a strong dose-dependent increase in risk associated with numbers of cigarettes smoked per day and a substantial reduction in risk for long-term former smokers. (C) 2004 Wiley-Liss. Inc.