Additive deleterious effects of methamphetamine dependence and immunosuppression on neuropsychological functioning in HIV infection
Additive deleterious effects of methamphetamine dependence and immunosuppression on neuropsychological functioning in HIV infection
复制标题
DOI：
10.1007/s10461-005-9056-4
复制
发表时间：
2006-03-01
影响因子：
4.4
通讯作者：
Grant, I
中科院分区：
文献类型：
--
作者：
Carey, CL;Woods, SP;Grant, I
甲基安非他明(MA)依赖和HIV感染与大脑功能障碍独立相关，特别是在额叶-基底神经节环路。最近的证据表明，MA依赖对与HIV感染相关的神经心理(NP)缺陷具有相加效应。这项研究通过检查MA依赖(MA+)和免疫抑制(即，CD4淋巴细胞计数200)对284名HIV+患者NP功能的综合影响，扩展了先前的发现。在四个人口学可比组中检查了NP损害的患病率：(1)MA+/CD4；200；(2)MA+/CD4；=200；(3)MA-/CD4；200；和(4)MA-/CD4&>200。结果显示，MA依赖和免疫抑制都是NP损害的显著预测因素。更重要的是，相加效应很明显，MA+/CD4<；200组表现出最高的NP损伤率。研究结果表明，MA依赖对免疫抑制的HIV感染者的NP状态有附加的有害影响，这可能反映了额纹状体回路的神经病理生理机制的综合作用。
Methamphetamine (MA) dependence and HIV infection are independently associated with cerebral dysfunction, especially within frontal-basal ganglia circuits. Recent evidence indicates that MA dependence has an additive effect on neuropsychological (NP) deficits associated with HIV infection. This study extends prior findings by examining the combined effects of MA dependence (MA+) and immunosuppression (i.e., CD4 lymphocyte count < 200) on NP functioning in 284 HIV+ individuals. Prevalence of NP impairment was examined in four demographically comparable groups: (1) MA+/CD4 < 200; (2) MA+/CD4 >= 200; (3) MA-/CD4 < 200; and (4) MA-/CD4 >= 200. Results revealed that both MA dependence and immunosuppression were significant predictors of NP impairment. More importantly, additive effects were evident whereby the MA+/CD4 < 200 group exhibited the highest rate of NP impairment. Findings indicate that MA dependence conveys an additive deleterious impact on NP status in immunosuppressed persons with HIV infection, perhaps reflecting the combined effects of neuropathophysiological mechanisms in fronto-striatal circuits.