Structure and function of the epidermis related to barrier properties
Structure and function of the epidermis related to barrier properties
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DOI：
10.1016/j.clindermatol.2011.08.007
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发表时间：
2012-05-01
影响因子：
2.7
通讯作者：
Wolf, Ronni
中科院分区：
文献类型：
--
作者：
Baroni, Adone;Buommino, Elisabetta;Wolf, Ronni
皮肤最重要的功能是在生物体的“内部”和“外部”之间形成屏障，防止病原体入侵，抵御化学攻击以及水和溶质的不受控制的损失。物理屏障主要位于角质层中，角质层由富含蛋白质的细胞和富含脂质的细胞间结构域组成。表皮分化和脂质组成的任何改变都会导致屏障功能改变，这是各种皮肤改变和疾病的中心事件。这一贡献提出了一个简单的描述皮肤的结构，注意负责皮肤屏障功能的最重要的组成部分。(C)2012年由Elsevier Inc.出版
The most important function of the skin is the formation of a barrier between the "inside" and the "outside" of the organism, which prevents invasion of pathogens and fends off chemical assaults as well as the unregulated loss of water and solutes. The physical barrier is mainly localized in the stratum corneum, which consists of protein-enriched cells and lipid-enriched intercellular domains. Any modifications in epidermal differentiation and lipid composition results in altered barrier function, a central event in various skin alterations and diseases. This contribution presents a brief description of the structure of the skin, paying attention to the most important components responsible for skin barrier function. (C) 2012 Published by Elsevier Inc.