Tolerability of antiseizure medications - Implications for health outcomes
Tolerability of antiseizure medications - Implications for health outcomes
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DOI：
10.1212/wnl.63.10_suppl_4.s9
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发表时间：
2004-11-23
期刊：
影响因子：
9.9
通讯作者：
Vahle, V
中科院分区：
文献类型：
--
作者：
Gilliam, F;Carter, J;Vahle, V
癫痫是一种异常兴奋性和神经元聚集体同步性的疾病，导致阵发性行为或知觉改变。大多数抗癫痫药物（AEDs）降低膜兴奋性或增加突触后抑制，并可能改变神经元网络的同步。AED降低癫痫发作倾向的特性可能会导致正常大脑活动的中断。先前的临床研究表明，这类aed的作用存在广泛的个体差异。在过去的十年中，抗癫痫治疗的选择已经大大扩大，现在允许针对个体患者进行最佳管理的干预。目前改善癫痫护理的策略应包括系统监测以识别AED的不良影响，未来的方法可能涉及创造性地应用神经影像学和遗传技术，以使患者特征与AED属性相匹配。
Epilepsy is a disorder of abnormal excitability and synchronicity of aggregates of neurons that lead to paroxysmal behavioral or perceptual change. Most antiepileptic drugs (AEDs) decrease membrane excitability or increase postsynaptic inhibition, and may alter synchronization of neuronal networks. The attributes of an AED that reduce the tendency toward seizures may cause disruption of normal cerebral processes. Previous clinical studies suggest wide inter-individual variability of the effects of such AEDs. The options for antiepileptic treatment have dramatically expanded in the past decade and now allow tailoring of intervention for optimal management of individual patients. Current strategies to improve epilepsy care should include systematic monitoring to identify adverse effects of AEDs, and future approaches may involve creative applications of neuroimaging and genetic technologies to match patient characteristics to AED attributes.