Short- and long-term reliability of language fMRI
Short- and long-term reliability of language fMRI
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DOI：
10.1016/j.neuroimage.2018.04.050
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发表时间：
2018-08-01
期刊：
影响因子：
5.7
通讯作者：
Lucas, Carolin Weiss
中科院分区：
文献类型：
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作者：
Nettekoven, Charlotte;Reck, Nicola;Lucas, Carolin Weiss
当使用功能磁共振成像（fMRI）映射重要的语言功能，高的重测信度是强制性的，无论是在基础科研和临床应用。因此，我们在一组健康受试者中使用图片命名任务和稀疏抽样fMRI协议系统地测试了fMRI的短期和长期可靠性。我们假设，重测信度可能会更高（一）语音相关的运动领域比其他语言领域和（二）短期相比，较长的闭会期间interval.16右撇子的主题（平均年龄：29岁）参加了三个会议分开2-6（会议1和2，短期）和21-34天（会议1和3，长期）。受试者被要求在每次功能磁共振成像中执行相同的公开图片命名任务（每次50张黑白图像）。使用以下测量来测试可靠性：（i）局部激活最大值和重心（CoG）之间的欧几里得距离（艾德），（ii）重叠体积和（iii）逐体素的组内相关系数（ICC）。对基于全脑组数据选择的三个感兴趣区域进行分析：结果表明，脑内主要运动皮层（M1）、颞上级回（STG）和额下回（IFG）的激活中心可靠性高，不依赖于时间间隔，与CoG（8.03 +/- 2.01 mm）相比，局部激动最大值（6.45 +/- 1.36 mm）的ROI或半球具有显著较小的艾德。与此相反，激活的程度显示相当低的可靠性值与重叠范围从24%（IFG）到56%（STG）。这里，左半球显示出比右半球显著更高的重叠体积。尽管所有ROI的平均ICC介于较差（ICC 0.75）之间。体素方面的可靠性不同的ROI的影响intersession interval. Together，我们可以表明，尽管相当大的ROI依赖的激活程度的变化随着时间的推移，高度可靠的激活中心，可以确定使用一个公开的图片命名范例。
When using functional magnetic resonance imaging (fMRI) for mapping important language functions, a high test-retest reliability is mandatory, both in basic scientific research and for clinical applications. We, therefore, systematically tested the short-and long-term reliability of fMRI in a group of healthy subjects using a picture naming task and a sparse-sampling fMRI protocol. We hypothesized that test-retest reliability might be higher for (i) speech-related motor areas than for other language areas and for (ii) the short as compared to the long intersession interval.16 right-handed subjects (mean age: 29 years) participated in three sessions separated by 2-6 (session 1 and 2, short-term) and 21-34 days (session 1 and 3, long-term). Subjects were asked to perform the same overt picture naming task in each fMRI session (50 black-white images per session). Reliability was tested using the following measures: (i) Euclidean distances (ED) between local activation maxima and Centers of Gravity (CoGs), (ii) overlap volumes and (iii) voxel-wise intraclass correlation coefficients (ICCs). Analyses were performed for three regions of interest which were chosen based on whole-brain group data: primary motor cortex (M1), superior temporal gyrus (STG) and inferior frontal gyrus (IFG).Our results revealed that the activation centers were highly reliable, independent of the time interval, ROI or hemisphere with significantly smaller ED for the local activation maxima (6.45 +/- 1.36 mm) as compared to the CoGs (8.03 +/- 2.01 mm). In contrast, the extent of activation revealed rather low reliability values with overlaps ranging from 24% (IFG) to 56% (STG). Here, the left hemisphere showed significantly higher overlap volumes than the right hemisphere. Although mean ICCs ranged between poor (ICC0.75) were found for all ROIs. Voxel-wise reliability of the different ROIs was influenced by the intersession interval.Taken together, we could show that, despite of considerable ROI-dependent variations of the extent of activation over time, highly reliable centers of activation can be identified using an overt picture naming paradigm.