Age-related fat deposition in multifidus muscle could be a marker for nonalcoholic fatty liver disease
Age-related fat deposition in multifidus muscle could be a marker for nonalcoholic fatty liver disease
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DOI：
10.1007/s00535-009-0147-2
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发表时间：
2010-02-01
影响因子：
6.3
通讯作者：
Fujimoto, Kazuma
中科院分区：
文献类型：
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作者：
Kitajima, Yoichiro;Eguchi, Yuichiro;Fujimoto, Kazuma
尽管非酒精性脂肪肝病（NAFLD）与内脏肥胖相关，但 NAFLD 患者内脏脂肪堆积与骨骼肌脂肪变性之间的关系尚未确定。我们评估了：（1）横断面研究中多裂肌组织脂肪变性、内脏脂肪积累和生化数据之间的关系，以及（2）纵向研究中体重减轻对多裂肌组织脂肪变性的影响。 纳入了 333 名 NAFLD 患者。通过计算机断层扫描评估肝脏脂肪变性、内脏脂肪面积和多裂肌/皮下脂肪衰减比（MM/F比）。为了评估饮食和运动带来的体重减轻如何影响 MM/F 比率，比较了体重减轻组和非体重减轻组之间 MM/F 比率的变化。MM/F 比率存在性别差异。 MM/F比值与年龄显着相关（男性r = 0.613，P < 0.01；女性r = 0.440，P < 0.01）。 MM/F比值与内脏脂肪面积呈正相关（男性：r = 0.262，P < 0.01；女性：r = 0.214，P < 0.01）。 MM/F比值的降低，伴随着内脏脂肪积累的减少，导致20名体重减轻的患者的肝脏脂肪变性得到缓解，但22名未体重减轻的患者的肝脏脂肪变性却没有减轻。MM/F比值与衰老和内脏脂肪积累密切相关。 MM/F 比值因体重减轻而改善，表明计算机断层扫描评估的多裂肌脂肪积累可能是 NAFLD 的治疗指标。
Although nonalcoholic fatty liver disease (NAFLD) is associated with visceral obesity, the relationship between visceral fat accumulation and skeletal muscle steatosis in patients with NAFLD has not been established. We evaluated: (1) the relationship between multifidus muscular tissue steatosis, visceral fat accumulation, and biochemical data in a cross-sectional study, and (2) the influence of weight reduction on multifidus muscular tissue steatosis in a longitudinal study.Three hundred thirty-three NAFLD patients were enrolled. Hepatic steatosis, visceral fat area, and the multifidus muscle/subcutaneous fat attenuation ratio (MM/F ratio) were evaluated by computed tomography. To evaluate how weight reduction produced by diet and exercise affected the MM/F ratio, changes in the MM/F ratio were compared between weight reduction and non-weight reduction groups.There was a gender difference in MM/F ratios. The MM/F ratio was significantly correlated with age (male r = 0.613, P < 0.01; female r = 0.440, P < 0.01). The MM/F ratio was positively correlated with visceral fat area (male: r = 0.262, P < 0.01; female: r = 0.214, P < 0.01). A decrease in the MM/F ratio, concomitant with reduced visceral fat accumulation, led to alleviation of hepatic steatosis in 20 patients with weight reduction, but not in 22 patients without weight reduction.The MM/F ratio was closely related to aging and visceral fat accumulation. The MM/F ratio was improved by weight reduction, indicating that fat accumulation in the multifidus muscle evaluated by computed tomography might be a therapeutic indicator of NAFLD.