CDNA CLONING AND REGIONAL DISTRIBUTION OF A NOVEL MEMBER OF THE OPIOID RECEPTOR FAMILY
CDNA CLONING AND REGIONAL DISTRIBUTION OF A NOVEL MEMBER OF THE OPIOID RECEPTOR FAMILY
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DOI：
10.1016/0014-5793(94)80603-9
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发表时间：
1994-04-18
期刊：
影响因子：
3.5
通讯作者：
SUGIMOTO, T
中科院分区：
文献类型：
--
作者：
FUKUDA, K;KATO, S;SUGIMOTO, T
我们使用源自 δ-阿片受体亚型 cDNA 的探针从大鼠大脑 cDNA 文库中克隆了阿片受体家族新成员的 cDNA，命名为 ROR-C。推导的ROR-C的氨基酸序列与ROR-A(大鼠δ阿片受体亚型)、ROR-B(大鼠mu亚型)和ROR-D(大鼠κ亚型)的氨基酸序列显示出高度同源性。 RNA印迹杂交和原位杂交分析表明ROR-C mRNA在大鼠中枢神经系统的离散区域中表达。
We have cloned a cDNA for a novel member of the opioid receptor family, designated as ROR-C, from the rat cerebrum cDNA library using the probe derived from the delta-opioid receptor subtype cDNA. The deduced amino acid sequence of ROR-C shows high homology with those of ROR-A (rat delta-opioid receptor subtype), ROR-B (rat mu-subtype) and ROR-D (rat kappa-subtype). RNA blot hybridization and in situ hybridization analysis revealed that ROR-C mRNA is expressed in discrete regions of the rat central nervous system.